Award Data

DESCRIPTION (provided by applicant): Hernial repair is the most frequent operation in general surgery for which synthetic meshes are commonly used in repairing abdominal defects. Frequently used meshes consist of non-absorbable polymers such as polypropylene, polyethylene terephthalate, or polytetrafluoroethylene. Recently established modifications of these meshes to improve them biomechanical com ...

DESCRIPTION (provided by applicant): Multiple sequence alignment (MSA) is a core element of bioinformatics, comparative genomics, phylogenetics, molecular, and structural biology. Several excellent software tools for MSA construction are heavily used by the biomedical community; however, essentially all automatically constructed MSAs require significant editing (error corrections) prior to their a ...

DESCRIPTION provided by applicant The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma especially in economically disadvantaged children CarboNix LLC proposes a Phase II SBIR research program that will result in commercialization of a new service business for abating multiple indoor allergens k ...

? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...

DESCRIPTION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had limited success on the insoluble proteins that are critical to biological function. Various recent developments have enhanced the effectiveness of solids NMR methods incorporating Magic Angle sample Sp ...

IN THE TREATMENT OF THE DYNAMIC PROBLEMS OF STRUCTURES, TWO ALTERNATE TESTING METHODS, BASED ON EXTERNAL AND EMBEDDED SENSORS, EXIST IN THE LITERATURE. IF THE SENSORS RESPOND TO THE CHANGES IN THE DYNAMIC CHARACTERISTICS OF THE STRUCTURE, AND/OR THE ENVIRONMENT, THEN THEY ARE REFERRED TO "SMART" STRUCTURES. SMART SENSORS AND SMART MATERIALS HAVE BEEN USED FOR DETECTING STRUCTURAL DAMAGES AND/OR CO ...

DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

DESCRIPTION (provided by applicant): Renal transplantation has been a clinical reality for nearly 40 years. Transplantation is the only effective solution for organ end-stage renal failure. Long term renal function following transplantation has been shown to be better when kidneys are not subjected to cold preservation storage. However, despite the fact that cold preservation elicits significant k ...

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...