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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. AAV2-ASPA-Based Metabolic Intervention for Alzheimer's Disease

    SBC: ASKLEPIOS BIOPHARMACEUTICAL, INC.            Topic: NIA

    Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A biomarker of aging as a predictor of kidney transplant function

    SBC: HEALTHSPAN DIAGNOSTICS, LLC            Topic: NIA

    ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Affinity Capture Peptides for Clinical Mass Spectrometric Assays in Plasma

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): We will develop the first assay for multiplexed combinations of all 14 Bone Morphogenetic Proteins. Immunoassays are the gold standard for measuring proteins in clinical samples. However these antibody- based tests neither quantitate protein analyte variants, nor multiplex across large numbers of superfamily members. In addition, the availability of polyclona ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Alternative human cell-based models of fatty liver disease

    SBC: Zen-Bio, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Obesity and Type 2 diabetes affect the lives of millions of people worldwide, add significantly to health-related expenditures, and are seemingly unmanageable health issues, since rates of occurrence are steadily increasing. In parallel with the increasing incidence of obesity and insulin resistance, is the occurrence of non-alcoholic fatty liver disease (NAFLD ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo

    SBC: GEM TOX CONSULTANTS AND LABS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The aim of this submission is to develop a quantitative microRNA assay for screening right and left colon cancer in stool of patients, particularly at the early adenoma stage (e.g., polyps 3 1 cm with high grade dysplasia), which shows higher sensitivity than FOBT, and results in better compliance and is more economical than invasive colonoscopy. We studied ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Amine-Boranes as New Topoisomerase II Inhibitors

    SBC: BORON BIOLOGICALS, INC.            Topic: N/A

    The main objective of the research is to develop a new class of topoisomerase II (Topo II) inhibitors as antineoplastic agents. In preliminary studies, heterocyclic amine-carboxyboranes have been shown to possess cytotoxic activity against a number of murine and human tumor tissue culture lines, e. g. P388, L1210, Tmolt3, HeLa-S3, lung bronchogenic, KB nasopharynx, glioma, and osteosarcoma. These ...

    SBIR Phase I 1993 Department of Health and Human Services
  7. AMONG THE MANY ALTERNATIVES POSSIBLE TO U.S. INDUSTRY, SUCCESSFUL EXPANSION OF THE RANGE OF MICROBES CAN HELP FIND WAYS TO UTILIZE LIGNOCELLULOSE AND TO SWITCH TO RENEWABLE RSOURCES FOR SPECIALTY CHEMICALS AND AWAY FROM PETROLEUM. IT CAN HELP REDUCE POLLU

    SBC: Triangle Research and Development Corporation            Topic: N/A

    N/A

    SBIR Phase I 1983 Department of Health and Human Services
  8. A New Dual-Gated MCT (DMCT) for Hybrid Electric Power Systems

    SBC: POWER TECHNOLOGY SERVICES (PTS), INC.            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of DefenseDefense Advanced Research Projects Agency
  9. A Novel Approach to the Treatment of Cardiac Arrhythmia: A Robotic Catheter for E

    SBC: LifeSciTech, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The primary objective of this Phase II research is to design, fabricate, and surgically evaluate a robotic catheter for endocardial ablation procedures. Phase I research successfully demonstrated the feasibility of this concept through the development of a tele-operated catheter prototype with shape memory alloy (SMA) actuated bending segments. Phase II researc ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Biomimetic Bone Cement For Immediately Loaded Dental Implants

    SBC: SOUTHEAST TECHINVENTURES INC            Topic: NIDCR

    DESCRIPTION (provided by applicant): The worldwide market for implant-based dental reconstruction products will approach nearly 3.5 billion by 2010 with an annual growth rate of 15%. Currently, an implant patient waits 3-14 months from the time of tooth extraction until a functioning crown is in place, resulting in significant inconvenience for the patient and high cost for the overall procedure. ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
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