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ABSTRACT / SUMMARY / PROJECT DESCRIPTION A single intramuscular injection of an adeno-associated virus (AAV) vector that expresses eCD4-Ig has the potential to treat or prevent HIV-1 infection for a lifetime. eCD4-Ig is a synthetic antibody or “immunoadhesin” constructed by fusing parts of the viral receptor (CD4) and coreceptor (CCR5) to the constant region of an antibody. Because eCD4-Ig bin ...

Pancreatic ductal adenocarcinomaPDACis a highly lethal form of cancerIn most patientsdetection is at an advanced stage and the outcome is poorThis project is directed towards development of a molecularly targeted ultrasound contrast agent with potential to detect early stage disease while still curableIn Phase I of this projectwe incorporated the engineered human single chain variable fragmentscFv ...

AbstractAn estimatedmillion colonoscopies are performed annually in the US at a cost of about $Bhowever current colonoscopes with forward vision fail to detectof precancerous polypsOverof the missed polyps are located on or behind numerous folds in the colon where they are hidden from the sight of a forward view colonoscopeIn this research proposalwe propose to complete our development of an imagi ...

DESCRIPTION provided by applicant Bladder cancer BCa is among the five most common malignancies worldwide In the US alone new BCa cases for are estimated at with estimated deaths at At presentation the majority of bladder tumors are non muscle invasive and can be treated by transurethral resection of the tumor however more than of patients with BCa will have a re ...

Project Summary/Abstract The proposed work is directed at the commercialization of BMSEEDandapos;s Micro-Electrode Array Stretching Stimulating und Recording Equipment (MEASSuRE) technology. MEASSuRE bridges the gap between in vitro and in vivo research by simulating the biomechanical and electrical environment of cells in the body in a controlled environment outside of the body. The applications ...

DESCRIPTION provided by applicant The neuromuscular assessment of children is uniquely challenging Unlike examination of the heart or lung the complete bedside assessment of the neuromuscular system requires the active participation of the child and results must be evaluated in the context of normal child development and degree of cooperation Moreover neuromuscular disease severity is highl ...

There is a need for soil gas analyzers to characterize subsurface biogeochemical processes by measuring simultaneously multiple gases that are signatures for specific processes. Instruments should be significantly more portable and require less power than what is currently available. The analyzers need to be suitable for field work and laboratory studies. How This Problem is Being Addressed: Rugge ...

Nitrous oxide is the third most important greenhouse gas (GHG,) with an atmospheric lifetime of ~114 years and a global warming impact ~300 times greater than that of CO2. The main cause of nitrous oxide’s atmospheric increase is anthropogenic emissions, and over 80% of the current global anthropogenic flux is related to agriculture, including associated land-use change. An accurate assessment o ...

DESCRIPTION provided by applicant Multiple myeloma MM is the second most commonly diagnosed hematologic malignancy with an estimated newly diagnosed cases and deaths due to MM in the United States in MM typically a disease of the elderly is a malignancy of clonal plasma cells in the bone marrow BM characterized by the presence of paraproteinemia destructive bone dise ...

DESCRIPTION provided by applicant Non small cell lung cancer NSCLC is the most common lung cancer Half of NSCLC shows WNT activation marking poor survival StemSynergy Therapeutics Inc SSTI has identified a family of WNT inhibitors based on a novel chemical scaffold with our lead molecule SST demonstrating efficacy against WNT driven colorectal cancer In Phase I SBIR studies many ...