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Abstract ProjectAdministrative Supplements to projectTools and Methods for Producing HighQuality Functional Protein Microarrays for Biomarker Discovery INanoBio is developing ProCap system capable of semi automated production of functional protein arrayswhich can be phosphorylatedde phosphorylated by kinasesphosphatases in high throughput formatin addition to other PTM modificationsAs described in ...

Project Summary AbstractHesperos will construct and test microscale multi organ systems with recirculating blood and cerebral spinal fluid surrogates that will give insights to the responses of various Alzheimer s phenotypes to drugs as well as the influence of peripheral effects on AD progressionspecifically ApoE variantsWe seek to leverage DrMorgan s research on Alzheimer s and aging combine it ...

DESCRIPTION provided by applicant In HIV pre exposure prophylaxis PrEP trials sub optimal oral and microbicide adherence has precluded accurate estimation of drug efficacy Measurement of adherence is a major unmet challenge Other objective measures of adherence in microbicide trials have been tested but none measure the actual use of the product We propose to rapidly develop an alternati ...

DESCRIPTION provided by applicant The proposed work is directed at the commercialization of a stretchable microelectrode array BMSEEDandapos s sMEA a new tool that provides enhanced capabilities to simultaneously interface mechanically and electrically with cell cultures in vitro The mechanical stretching of neurons in the brain or spinal cord is often te root cause of traumatic brain injur ...

DESCRIPTION provided by applicant VisionQuest Biomedical and its collaborators have assembled a team of inter disciplinary scientists with considerable experience in automated retinal image analysis clinical ophthalmology with specialized research in malarial retinopathy MR and cerebral malaria diagnosis CM This team will develop and test an automated MR screening software system integra ...

Project SummaryBoth older adults and the pharmaceutical industry would benefit from the development of human on a chip systems to be able to systematically investigate disease comorbidities and their response to drug candidates in the aged population at the preclinical stage due to the lack of good multimodal models of disease combinationsWe will investigate diseases that are most prevalent in the ...

Inspired TherapeuticsMerritt Island FLis developing a simplecost effectivemechanical circulatory supportMCSsystemINSPIRETMdesigned as a single driver with interchangeable pumps for multiple pediatric and adult cardiopulmonary indications and operational settingsThe goal of this phase I study is to continue development and demonstrate feasibility for pediatric left ventricular assist deviceLVADsupp ...

DESCRIPTION provided by applicant This SBIR Phase I project will develop a novel mobile framework to measure left ventricular ejection fraction as a marker for systolic dysfunction using automated non invasive analysis of cardiac signals Heart disease is the leading cause of death for men and women accounting for more than one third of all U S deaths In total costs associated w ...

DESCRIPTION (provided by applicant): Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) and asthma affect millions of people worldwide. Because there is no permanent cure for thesediseases, efficient management of the patients over their entire lifetime are needed, which becomes increasingly difficult with the rapid rise i ...

Abstract SignificanceInfantile Pompe DiseaseIPDis an autosomal recessive glycogen storage disorder caused by a deficiency of acid alpha glucosidaseGAAleading to accumulation of glycogen in lysosomesprimarily in skeletalcardiac and smooth musclesUntreated IPD infants die within the firstyears of lifeEnzyme replacement therapyERTwith recombinant human GAArhGAAimproves survival and quality of lifebut ...