Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Automation and validation of human on a chip systems for drug discovery

    SBC: Hesperos, Inc.            Topic: 950

    Project Summary AbstractOur overall strategy for Hesperos is to utilize microphysiological systems in combination with functional readouts to establish platforms capable of analysis of chemicals and drug candidates for toxicity and efficacy during pre clinical testingThis is a service based company that is developing low cost in vitro systems containing a novelpumplessmicrophysiological platform a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Development of AAV vectors for long-term expression of eCD4-Ig

    SBC: EMMUNE, INC.            Topic: NIAID

    ABSTRACTSUMMARYPROJECT DESCRIPTION A single intramuscular injection of an adeno associated virusAAVvector that expresses eCDIg has the potential to treat or prevent HIVinfection for a lifetimeeCDIg is a synthetic antibody orimmunoadhesinconstructed by fusing parts of the viral receptorCDand coreceptorCCRto the constant region of an antibodyBecause eCDIg binds the HIVenvelope glycoproteinEnvthrough ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Pancreatic Ductal Adenocarcinoma Targeted Ultrasound Contrast Agent Development

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Pancreatic ductal adenocarcinomaPDACis a highly lethal form of cancerIn most patientsdetection is at an advanced stage and the outcome is poorThis project is directed towards development of a molecularly targeted ultrasound contrast agent with potential to detect early stage disease while still curableIn Phase I of this projectwe incorporated the engineered human single chain variable fragmentscFv ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Dual View Endoscopy for Colonoscopy

    SBC: Omniscient Imaging, Inc.            Topic: 102

    AbstractAn estimatedmillion colonoscopies are performed annually in the US at a cost of about $Bhowever current colonoscopes with forward vision fail to detectof precancerous polypsOverof the missed polyps are located on or behind numerous folds in the colon where they are hidden from the sight of a forward view colonoscopeIn this research proposalwe propose to complete our development of an imagi ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development of molecular assays for non-invasive bladder cancer detection

    SBC: NONAGEN BIOSCIENCE CORPORATION            Topic: 102

    DESCRIPTION provided by applicant Bladder cancer BCa is among the five most common malignancies worldwide In the US alone new BCa cases for are estimated at with estimated deaths at At presentation the majority of bladder tumors are non muscle invasive and can be treated by transurethral resection of the tumor however more than of patients with BCa will have a re ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A device for rapid, painless, bedside muscle evaluation of children with neuromus

    SBC: Myolex Inc            Topic: 105

    DESCRIPTION provided by applicant The neuromuscular assessment of children is uniquely challenging Unlike examination of the heart or lung the complete bedside assessment of the neuromuscular system requires the active participation of the child and results must be evaluated in the context of normal child development and degree of cooperation Moreover neuromuscular disease severity is highl ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma

    SBC: Altor Bioscience LLC            Topic: 102

    DESCRIPTION provided by applicant Multiple myeloma MM is the second most commonly diagnosed hematologic malignancy with an estimated newly diagnosed cases and deaths due to MM in the United States in MM typically a disease of the elderly is a malignancy of clonal plasma cells in the bone marrow BM characterized by the presence of paraproteinemia destructive bone dise ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a WNT Inhibitor for Advanced Stage Lung Cancer

    SBC: Stemsynergy Therapeutic            Topic: 102

    DESCRIPTION provided by applicant Non small cell lung cancer NSCLC is the most common lung cancer Half of NSCLC shows WNT activation marking poor survival StemSynergy Therapeutics Inc SSTI has identified a family of WNT inhibitors based on a novel chemical scaffold with our lead molecule SST demonstrating efficacy against WNT driven colorectal cancer In Phase I SBIR studies many ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Transdermal H2S Sensing Device for Monitoring Peripheral Artery Disease

    SBC: EXHALIX, LLC            Topic: NHLBI

    Project Summary Abstract Peripheral artery diseasePADand small vessel diseaseSVDare the consequences of damage to the endothelial cells that line all vesselsboth leading to inadequate skin perfusion and end organ and limb damageIt is prevalent in diabetic patient population in which nearlysuffers from PAD and SVDThe proposed effort addresses an unmet need for early diagnosis of PAD and SVD in this ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Electrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders.

    SBC: Myolex Inc            Topic: NINDS

    Project SummaryTo improve the efficiencyconvenience and quality of ALS clinical trialswe need better biomarkers for assessing amyotrophic lateral sclerosisALSprogression and response to therapyAll recent ALS trials require patients to visit an ALS clinical trials center everymonths at which time assessments are obtainedincluding limb strengthvital capacityand the ALS functional rating scale revise ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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