Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Validation of a salivary miRNA diagnostic test for autism spectrum disorder

    SBC: Quadrant Biosciences Inc.            Topic: 103

    Autism spectrum disorderASDis a continuum of neurodevelopmental characteristics that includes deficits in communication and social interactionas well as restrictiverepetitive interests and behaviorsASD is an increasing public health concernwith aboutinAmerican children diagnosed with ASD inafold increase in prevalence over the pastyearsThe effect of ASD on both society and the economy is a large b ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Painless Defibrillation

    SBC: Coridea, LLC            Topic: NHLBI

    Project SummaryThe purpose of the proposed work is first in man testing of novel painless defibrillationPaDetherapySudden cardiac arrestSCAremains the number one killer in western civilizationThe underlying mechanism of SCA is usually ventricular fibrillationVFand survival depends on prompt defibrillationExisting defibrillators rely on the delivery of a brief high voltage shock to the heartWhile t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of Anti-ceramide scFv as Mitigator of the Radiation GI Syndrome

    SBC: Ceramedix Holding, LLC            Topic: NIAID

    Project Summary Abstract Inhibition of ceramide protects mice from death from the Radiation GI SyndromeRGSAdministration of anticeramide single chain FvscFvh post radiation exposure increases survival in intestinal stem cells and dramatically improves overall survival in miceThese data indicate that anti ceramide scFv represents the first effective mitigator of lethal RGSTo advance the development ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Splice sensors for cancer drug discovery

    SBC: Lucerna Inc.            Topic: 102

    SUMMARYRNA splicing plays a central role in the generation of proteome diversity and in gene regulationSplicing impacts vital cellular processessuch as cell fate and differentiationacquisition of tissue identityand organ developmentThusdefects in splicing has been linked to many diseasesincluding spinal muscular atrophyDuchenne muscular dystrophyParkinson s diseaseand several types of cancerRNA sp ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Minimally Invasive Cardiac Sympathetic Denervation for Malignant Ventricular Arrhythmia

    SBC: Coridea, LLC            Topic: NHLBI

    Sympathetic innervation of the heart plays a critical role in arrhythmogenesis and recent studies have highlighted the role of surgical sympathetic denervation in management of refractory ventricular arrhythmiasThe procedure although safe is very invasive and performed via thoracoscopy using single lung ventilationThis is not tolerated by patients with lung disease or severe structural heart disea ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Expressive Speech Synthesis for Speech-Generating Devices

    SBC: SYNFONICA LLC            Topic: NIDCD

    Project SummaryThe expression of emotions through speech is an essential element of human communicationyet individuals with speech impairments who rely on speech generating devicesSGDsto talk are largely deprived of this communicative channelNo one should be forced to sound blaswhen in fact they re elated or to sound apathetic when they intend to scoldWhile certain expressive speech modes are offe ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Small Animal Model as a Source of Therapy-Bound Single-Chain Antibody Products

    SBC: INGENIOUS TARGETING LABORATORY INC.            Topic: NIAID

    Project Summary Genetically modified mouse models have proven to be essential for the production of antibody related biological drugsbiologicsTo datethe majority of biologics originate from mouse modelsand small animal models are used not only to generate the antibodiesbut also as a platform for further optimization and testing of the biologicsUnmet NeedCamelid based antibodieswhich have superior ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Molecular Diagnostic Test for Early Onset of Lyme disease

    SBC: BIOSCIENCE DEVELOPMENT INC            Topic: NIAID

    Project Summary Abstract There is no validated assay to reliably detect the early onset of the Lyme disease infection at the time when antibiotic therapy has the best chance of a cure without sequelaeDiagnosis is often difficult because most symptoms are often nebulouswith the telltalebulls eyerash only appearing and clearly recognizable in approximately half of casesThe standard types of infectio ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Electronic Optimization of Stem Cell Derived Human Cardiac Myocytes

    SBC: Cytocybernetics Inc            Topic: NHLBI

    Project Summary As part of the FDA approval process for novel therapeutic drugssafety screening demonstrating that the candidate drug does not have deleterious effects on the human cardiac action potential is requiredHealthy human heart cells are not available for such preclinical drug testingThere is currently no consensus on the best experimental approach to provide the most efficienteconomicala ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. High Subzero Equilibrium VCA Cryopreservation

    SBC: Sylvatica Biotech, Inc.            Topic: NIAID

    PROJECT SUMMARYABSTRACT Short tissue preservation times impose numerous constraints on transplantation by contributing to organ shortageexacerbating ischemic injury and graft rejectionand diminishing the length and quality of life for transplant recipientsFor vascular composite allograftVCAthe current standard of preservation for clinical transplantationof a few hours of hypothermic static storage ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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