Award Data

Autism spectrum disorderASDis a continuum of neurodevelopmental characteristics that includes deficits in communication and social interactionas well as restrictiverepetitive interests and behaviorsASD is an increasing public health concernwith aboutinAmerican children diagnosed with ASD inafold increase in prevalence over the pastyearsThe effect of ASD on both society and the economy is a large b ...

Project SummaryThe purpose of the proposed work is first in man testing of novel painless defibrillationPaDetherapySudden cardiac arrestSCAremains the number one killer in western civilizationThe underlying mechanism of SCA is usually ventricular fibrillationVFand survival depends on prompt defibrillationExisting defibrillators rely on the delivery of a brief high voltage shock to the heartWhile t ...

Project Summary Abstract Inhibition of ceramide protects mice from death from the Radiation GI SyndromeRGSAdministration of anticeramide single chain FvscFvh post radiation exposure increases survival in intestinal stem cells and dramatically improves overall survival in miceThese data indicate that anti ceramide scFv represents the first effective mitigator of lethal RGSTo advance the development ...

SUMMARYRNA splicing plays a central role in the generation of proteome diversity and in gene regulationSplicing impacts vital cellular processessuch as cell fate and differentiationacquisition of tissue identityand organ developmentThusdefects in splicing has been linked to many diseasesincluding spinal muscular atrophyDuchenne muscular dystrophyParkinson s diseaseand several types of cancerRNA sp ...

Sympathetic innervation of the heart plays a critical role in arrhythmogenesis and recent studies have highlighted the role of surgical sympathetic denervation in management of refractory ventricular arrhythmiasThe procedure although safe is very invasive and performed via thoracoscopy using single lung ventilationThis is not tolerated by patients with lung disease or severe structural heart disea ...

Project SummaryThe expression of emotions through speech is an essential element of human communicationyet individuals with speech impairments who rely on speech generating devicesSGDsto talk are largely deprived of this communicative channelNo one should be forced to sound blaswhen in fact they re elated or to sound apathetic when they intend to scoldWhile certain expressive speech modes are offe ...

Project Summary Genetically modified mouse models have proven to be essential for the production of antibody related biological drugsbiologicsTo datethe majority of biologics originate from mouse modelsand small animal models are used not only to generate the antibodiesbut also as a platform for further optimization and testing of the biologicsUnmet NeedCamelid based antibodieswhich have superior ...

Project Summary Abstract There is no validated assay to reliably detect the early onset of the Lyme disease infection at the time when antibiotic therapy has the best chance of a cure without sequelaeDiagnosis is often difficult because most symptoms are often nebulouswith the telltalebulls eyerash only appearing and clearly recognizable in approximately half of casesThe standard types of infectio ...

Project Summary As part of the FDA approval process for novel therapeutic drugssafety screening demonstrating that the candidate drug does not have deleterious effects on the human cardiac action potential is requiredHealthy human heart cells are not available for such preclinical drug testingThere is currently no consensus on the best experimental approach to provide the most efficienteconomicala ...

PROJECT SUMMARYABSTRACT Short tissue preservation times impose numerous constraints on transplantation by contributing to organ shortageexacerbating ischemic injury and graft rejectionand diminishing the length and quality of life for transplant recipientsFor vascular composite allograftVCAthe current standard of preservation for clinical transplantationof a few hours of hypothermic static storage ...