Award Data

The objective in this project is to implement and validate a probabilistic qualification framework that will enable additive manufacturing (AM) materials and part qualification through the use of a data-driven predictive model within a statistical framework. Senvol seeks to develop and validate a data-driven ICME probabilistic framework for assisting qualification of AM materials and parts. Phase ...

Autism spectrum disorder (ASD) is a continuum of neurodevelopmental characteristics that includes deficits in communication and social interaction, as well as restrictive, repetitive interests and behaviors. ASD is an increasing public health concern, with about 1 in 45 American children diagnosed with ASD in 2014, a 10-fold increase in prevalence over the past 40 years. The effect of ASD on both ...

DESCRIPTION (provided by applicant): Phase I: It has become increasingly clear that the metastatic potential of solid cancer best correlates with the nature of the cells emigrating from the primary tumors. These emigrating cells enter the circulatory system and thus can readily be recovered using a simple and minimally invasive procedure. However, molecular analysis of these cells remains technic ...

Superconductor digital circuits, operating at very high clock speed, can directly process wideband digitized radio frequency (RF) signals. By integrating such digital processing circuitry together with superconductor analog-to-digital converters (ADCs), we propose to develop the next generation digital-RF receivers. Leveraging the recent development of multiple superconductor ADCs on the same chip ...

The Navy and other government-sponsored agencies use the P-3 aircraft. Due to the diverse missions and limited number of P-3 aircraft, the most economical and expeditious way to enhance operations and assure crew safety would be to incorporate low-cost expendable tactical unmanned air vehicles (UAV's). If UAVs were incorporated into each P-3, a load-out of sonobuoy launched UAV's with interchange ...

AbstractAn estimatedmillion colonoscopies are performed annually in the US at a cost of about $Bhowever current colonoscopes with forward vision fail to detectof precancerous polypsOverof the missed polyps are located on or behind numerous folds in the colon where they are hidden from the sight of a forward view colonoscopeIn this research proposalwe propose to complete our development of an imagi ...

DESCRIPTION (provided by applicant): Phase I Reflectance confocal microscopy images the cellular and structural morphology of tissue in-vivo or ex-vivo without the need for histological processing. Existing reflectance confocal microscopes use single wavelength laser to generate gray scale intensity images. The goals of this proposal are to build and characterize a coherence reflectance c ...

DESCRIPTION (provided by applicant): Solidus Biosciences, Inc. is developing a proprietary Metabolizing Enzyme Toxicology Assay Chip (MetaChip), along with a xenobiotic metabolism and toxicity screening device that uses these chips (the MetaReader), for high- throughput analysis of drug metabolism and toxicity. The MetaChip integrates the high-throughput metabolite- generating capability of P450 c ...

Project Summary As part of the FDA approval process for novel therapeutic drugssafety screening demonstrating that the candidate drug does not have deleterious effects on the human cardiac action potential is requiredHealthy human heart cells are not available for such preclinical drug testingThere is currently no consensus on the best experimental approach to provide the most efficienteconomicala ...

DESCRIPTION provided by applicant Photolitecandapos s patented technology is focused on developing improved agents for tumor imaging image guided surgery and or photodynamic therapy PDT The proposed STTR proposal includes fluorescence image guided PDT a andquot See and Treatandquot approach The fluorescence imaging compound with long wavelength absorption near nm should be extremel ...