Award Data

DESCRIPTION provided by applicant Acute and chronic pain resulting from injury surgery or disease afflicts andgt million Americans each year having a severe impact on mood mental health and quality of life and costing the U S approximately $ billion in economic costs annually For many patients treatment options provide inadequate relief because of the shortcomings of available th ...

DESCRIPTION provided by applicant Diffuse large B cell lymphoma DLBCL represents one of the most common variants of Non Hodgkinandapos s lymphoma NHL and oncogenic herpesviruses EBV and KSHV are the etiologic agents for the majority of these tumors in patients over or those infected with the human immunodeficiency virus HIV Despite modest improvements in outcomes for patients rece ...

DESCRIPTION provided by applicant Exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions including the detonation of andquot dirty bombsandquot is a significant public health concern The lung is particularly susceptible to ionizing radiation injury from external sources or inhalation of radioactive particles from radioactive fall out Radiation pneumono ...

DESCRIPTION provided by applicant Hemoglobinopathies are the most common monogenic diseases with approximately of the worldandapos s population being carriers Sickle cell disease SCD and thalassemia are primarily hemoglobin disorders The current SCD diagnostic methods require expensive equipment and are performed by highly trained laboratory technologists Presently there are no simple ...

DESCRIPTION provided by applicant AMPA glutamate receptors mediate the majority of fast excitatory neurotransmission in the central nervous system Four AMPA receptor subunits exist GluA GluA with functional channels containing various combinations of these four subunits Dysregulation of AMPA receptor expression has been reported in many neurological disorders including amyotrophic latera ...

DESCRIPTION provided by applicant Cells require the ability to detect and respond to stimuli in their surroundings including to endogenous metabolites exogenous nutrients and environmental irritants The proteins that are responsible for this process are called chemosensors and are involved in regulating diverse biological processes involved in pain sensation dietary preference and metabol ...

DESCRIPTION provided by applicant As anyone who has had an eye injury or even a small foreign object in the eye knows the cornea and surrounding structures are exquisitely sensitive to physical trauma Ocular pain can be agonizing paralyzing and extremely distressing to both the affected person and particularly in the case of pediatric cases family members who may feel powerless to help S ...

DESCRIPTION provided by applicant In this NIH SBIR Phase II Actuated Medical Inc will finalize and clinically test the andquot Active Fine Gauge Spinal Needle with CSF Sensing to Minimize PDPH and Dura Damage andquot Phase I achieved all Specific Aims and demonstrated that the Smooth Insertion Spinal SIS System provided greater control for the clinician by reducing the buckling of G tra ...

DESCRIPTION provided by applicant Ion channels such as Kv and Nav are involved in a number of human disorders including autoimmunity and pain that affect andgt million Americans annually and are poorly treated However ion channels are typically exceptionally difficult to express at high levels due to their structural complexity and toxicity s a result many research and therapeu ...

DESCRIPTION provided by applicant Optofluidics Inc proposes to develop a near field optical chromatograph the BioPrism and apply it to the characterization of particle coating stability in nanomedicine According to clinicaltrials gov about of all clinical trials involv nanoparticles and the National Science Foundation has predicted that nearly half of future pharmaceuticals will have s ...