Award Data

Protein manufacturing is of paramount importance to chemical and biological defense applications. Existing protein purification methods primarily rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermeasures to chemical and biological threats. To overcome these limitations, the overall goal of th ...

Safe and efficient ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these limitations, we propose to develop and demonstrate a novel bioaerosol ionization and collectio ...

A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon Parabons existing software for DNA origami design, this project will result in software that can be used to design a ...

In Phase I RANCOR successfully demonstrated an innovative enabling humidity control technology to provide very low humidity air to water sensitive, fully reusable CO2 adsorbents. The use of adsorbents enables complete reusability/rechargability and reduces the total heat load on the SCBA to the point where ice or other cooling systems will no longer be required. In Phase II Paragon will introduce ...

The recent use of organophosphate (OP) nerve agents against combatants and civilians in Syria has validated the importance of developing new drugs and biologics that sequester and catalytically degrade organophosphate (OP) nerve agents in the body before they cause morbidity and mortality. We propose to develop a method for the sequestration of OP simulants via porphyrin-DNA constructs. Construc ...

Countering the threat of intoxication by organophosphorus nerve agents is an important mission for homeland security. Currently, the most promising strategy is to bioscavenge the agents using injectable plasma-derived butyrylcholinesterase (BuChE) that has low substrate specificity and may offer a broad spectrum protection against OP agents. Human plasma-derived BuChE at 400mg IV dose is prophylac ...

The development of carbon-based nano-additive bound polymers with enhanced adsorption capacity and reactivity for the neutralization of chemical and biological warfare agents could cause substantial saving of life during CBWA threats. In the Phase I pr

This Phase II SBIR proposal is for the development of a miniaturized real-time visible/UV spectrometer prototype based on micro-opto-electro-mechanical systems (MOEMS) technology. Use of MOEMS technology enables orders of magnitude reductions in size, we

Luna will develop a hermetic closure system for use on combat uniforms and shelters that require protection from chemical and biological (CB) warfare agents. Despite great advances in high barrier fabrics, selectively permeable membranes, and unique chemical absorbent technologies, closures for clothing and shelters still possess the greatest risk for chemical or biological breach. Instead of mo ...