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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development and Commercialization of Predictive Biomarker Panel and In Office Kit for the Management of Diabetic Macular Edema

    SBC: OCULAR PROTEOMICS, LLC            Topic: N

    Abstract Diabetic Macular Edema DME is a vision threatening stage in Diabetic Retinopathy DR that can result in legal blindness The biochemical mechanisms that drive DME progression are not well understood and treatments address only portions of the disease pathology The available treatment options vary widely from injectable anti VEGF to injectable steroids to laser treatments and carry a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. AVGN7, a Novel Gene Therapeutic for Treating Cancer Cachexia

    SBC: Aavogen, Inc.            Topic: 102

    PROJECT SUMMARYThe skeletal muscle wasting that occurs with cancer cachexia compromises quality of life and is both directly and indirectly responsible for cancer mortalitiesTumor derived and tumor responsive factors as well as many therapeutics themselves contribute to the cachectic statealthough nutritional support has little if any positive effect on restoring striated muscle mass or functionTh ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Novel Plasma Based Microsatellite Instability Diagnostic for Guiding Immunotherapy

    SBC: Personal Genome Diagnostics Inc.            Topic: 102

    Abstract Immune checkpoint inhibitors have recently emerged as a revolution in cancer care providing the potential for durable response and improved survival for numerous cancer patients across multiple cancer types However only of patients who are treated with checkpoint inhibitors have responded in most cancer types necessitating biomarker assays that can reliably and accurately ident ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a companion diagnostic to predict response to cetuximab in patients with head and neck squamous cell carcinoma

    SBC: Biomarker Strategies, LLC            Topic: 100

    ABSTRACT Head and neck squamous cell carcinoma HNSCC is the world s th leading cause of cancer accounting for of cancer mortality For many other cancers molecular characterization has led to sub classification of disease based on the status of oncogenic drivers in signal transduction pathways leading to the development of molecularly targeted agents MTAs targeting specific dysregulate ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Novel Targeted Nanomedicine Delivering MicroRNA-30-5p ReplacementTherapy for Multi-drug Resistant Cancer Treatment

    SBC: Mirecule, Inc.            Topic: NCI

    AbstractIn this SBIR application miRecule proposes to develop a microRNA based therapeutic mimic of miRpmiRecule candidate MCfor the treatment of multi drug resistantMDRcancersHead and Neck Squamous Cell CarcinomaHNSCCis theth most common form of cancerGreater than half of patients present with late stage III or IV diseasewith an averageyear survival rate ofHNSCC tumors have high levels of genetic ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Polyionic Papillomavirus like Particles VLP for the Treatment of HPV oropharyngeal squamous cell carcinomas OPCs

    SBC: PATHOVAX, LLC            Topic: 102

    The broader impact commercial potential of PathoVax s STTR phase I proposal is to improve outcomes of cancer immuno therapy utilizing a vaccine formulation combining an immunogenic chimeric virus like particle cVLP vaccine with FDA approved immune check point inhibitors PathoVax proposes to develop this technology for treatment of human papillomavirus HPV associated cancers However cancer ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Knowledge and Usage of Lactation using Education and Advice from Support Network KULEA NET

    SBC: Benten Technologies Inc            Topic: NIMHD

    PROJECT SUMMARY ABSTRACT Breastfeeding has the potential to reduce health disparities associated with infant mortality and morbidity Breastfeeding rates by ethnicity in the United States show a marked disparity in African American AA women as compared to other groups Barriers to breastfeeding are complex with literature citing a lack of knowledge poor family and social support inhibiting soc ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Systematic Medical Approach to Reward Transformation SMART for Brain Health in Opioid Use Disorder

    SBC: Versa Integrated Solutions, Inc.            Topic: 102

    Summary In recent years opioid use disorder OUD and deaths due to opiate overdose e g with heroin fentanyl oxycodone in suburban and rural non minority groups has created an urgency for approaches to stem this epidemic but the rise in OUD and opiate overdose deaths has occurred in inner cities at similar rates Heroin misuse and addiction are persistent problems in African American commu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biomimetic Wound Healing Devices to Close Diabetic Wounds

    SBC: PROTEIN GENOMICS INC.            Topic: NIDDK

    The long term objective of this project is the synthesis and assembly of wound healing devices that mimic as closely as possible the biochemical and mechanical characteristics of healthy human skin The proposed research would focus on the synthesis of membranes containing electrospun human recombinant tropoelastin and collagen mixtures The ratios of the two molecules and the spinning condition ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A highly specific NIRF PET probe for the detection of cancer and metastases

    SBC: Imol Radiopharmaceuticals, LLC            Topic: 393

    This project will explore the translational potential of a new PET molecular imaging probe Ga PC for detecting very small cancers and distinguishing between localized and metastasized cancers in bone and soft tissue mouse models Ga PC will be evaluated for metastatic prostate PC and pancreatic PaCa cancers Early detection of the most lethal PaCa with andlt survival for y ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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