Award Data

ABSTRACT: Current methods for inspecting aircraft engine inlet and exhaust cavities are labor intensive and error prone. Airmen crawl into ducts looking for defects, trace suspected sites on Mylar sheets noting their position relative to cavity features, and manually enter the data into an aircraft assessment system. Technology that can reduce inspection times and eliminate sources of human err ...

DESCRIPTION: The HIV pandemic is one of the greatest public health challenges in history. It is estimated that 33 million people are living with HIV and 2.7 million of those are newly infected In a number of developed countries, the risk of death associated with HIV-1 infection has sharply declined due to the use of highly active antiretroviral therapy (HAART). Unfortunately, the rate of new HIV i ...

DESCRIPTION provided by applicant The proposed project will further develop marketable ELISA and lateral flow immunoassay diagnostics LFI in both monoplexed and multiplexed formats for the NIAID category A BSL filoviruses and will drive pre clinical development and validation for these diagnostics These assays will be used for diagnosis of Ebola virus EBOV Sudan virus SUDV and Marbu ...

DESCRIPTION (provided by applicant): Malaria causes 500 million clinical cases and gt 1 million deaths annually, is responsible for a loss of gt 1.3% of GDP in Africa annually, and is a serious concern for travelers and the military. A vaccine would be the ideal preventive and is perhaps the only intervention that could facilitate eradication of the disease. When attenuated P. falciparum sporozoi ...

DESCRIPTION (provided by applicant): Breast cancer is the most prevalent malignancy among women. Its awareness and screening have resulted in the majority of breast cancers being diagnosed in the early-stage, for which breast conservation therapy (BCT) has become the standard of care. BCT consists of a lumpectomy followed by 6-8 weeks of radiation therapy, mostly irradiating whole breast. Althoug ...

Long-duration wide-area surveillance missions increasingly are space-based. MEO orbits offer space-based radar systems more time on station, but require very large array apertures on the order of 100m in diameter. Achieving larger apertures with smaller, lighter launch packages and stable on-orbit pointing is a challenge that E-Textiles promises to meet. Textile processes can be used to achieve a ...

DESCRIPTION provided by applicant Encephalitis and meningitis are potentially fatal diseases defined by acute inflammation of the brain or protective membranes covering the brain and spinal cord These diseases can be caused by viruses bacteria fungi parasites or amoeba and disproportionately affect children the elderly or the immunocompromised Viruses are the most common cause of enceph ...

DESCRIPTION provided by applicant Human rhinoviruses HRV are the leading cause of common colds and virus induced exacerbation of asthma and chronic pulmonary diseases In addition HRV can cause severe lower respiratory tract infections in children the elderly and immune compromised patients The economic burden of the common cold is estimated to be about $ B each year in the US in terms o ...

DESCRIPTION provided by applicant The ideal most effective tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths is a highly effective vaccine that prevents blood stage infection and thereby prevents both disease and transmission Sanariaandapos s goal is to develop and commercialize a Pf sporozoite SPZ vaccine that prevents Pf blood stage infect ...

DESCRIPTION (provided by applicant): Autism is prevalent (1 in 50 children) and impairing but early intervention has been shown to improve outcomes prompting recommendations for screening at both two year and 18 month health check-ups. Detection of autismearly is crucial but accurate screening tools have been elusive. In Phase II, a practical method of improving accuracy of M-CHAT, the most widely ...