Award Data

DESCRIPTION (provided by applicant): Disorders of iron metabolism are among the most common human diseases. During the last decade, rapid progress has been made in understanding the molecular basis of iron homeostasis and its disorders. The peptide hormonehepcidin has emerged as the master regulator of iron metabolism. Dysregulation of hepcidin is the principal or contributing factor in most syste ...

DESCRIPTION provided by applicant Disorders of iron metabolism are among the most common human diseases During the last decade rapid progress has been made in understanding the molecular basis of iron homeostasis and its disorders The peptide hormone hepcidin has emerged as the master regulator of iron metabolism Dysregulation of hepcidin is the principal or contributing factor in most syst ...

Hardware- and software-in-the-loop models offer an efficient and scalable approach for analysis of heterogeneous communication networks. A virtual laboratory that integrates a physical test-bed with a much larger simulated network, can incorporate realistic physical effects while simultaneously scaling the analysis to much larger networks than are realizable with a purely physical testbed. The e ...

The U.S. Navy increases longevity of military platforms by upgrading key subsystems and components. Download of flight data has always been time consuming operation requiring participation of ground crew. POC offers a new download solution to efficiently transfer large amounts of flight data wirelessly with a seamless interface to the current flight data analysis software. At present, this data ...

DESCRIPTION provided by applicant Rapid and accurate identification of highly infectious and pathogenic disease is extremely important for the early forecast of outbreak risk and the effective deployment of medical and administrative countermeasures Unfortunately current diagnostics for use at the point of care POC are largely immunological assays that often lack adequate sensitivity speci ...

DESCRIPTION provided by applicant Mortality rates associated with Marburg virus MARV outbreaks range from to over MARV is included by the Centers for Disease Control and Prevention as among the Category A agents or andquot high priority agents that pose a risk to national security andquot MARV not only causes acute and terrifying disease but it is relatively stable in wet or ...

DESCRIPTION (provided by applicant): In Phase I of this SBIR, ImmPORT Therapeutics and the UCI Proteomics Core developed a high throughput gene cloning and protein expression platform that allowed the proteomes of any sequenced infectious agent to be expre ssed and printed onto microarray chips. Since Phase I we have cloned and expressed ~15,000 genes from nearly 20 different pathogens associated ...

This SBIR Phase II project will manufacture and test under high power laser loading a full-scale DM matched to ABL requirements. This TRL 6 prototype will be 30 cm in diameter with 1.875 cm spaced actuators – identical to the current ABL DM. However, the new DM has 14 microns stroke compared to 8 microns currently and has a negligible thermal ripple of 0.006 microns peak-to-valley after 200 se ...

Long-duration wide-area surveillance missions increasingly are space-based. MEO orbits offer space-based radar systems more time on station, but require very large array apertures on the order of 100m in diameter. Achieving larger apertures with smaller, lighter launch packages and stable on-orbit pointing is a challenge that E-Textiles promises to meet. Textile processes can be used to achieve a ...

DESCRIPTION (provided by applicant): The primary focus of this Phase II proposal is development of a product against Alzheimer's disease (AD). AD is an increasingly important cause of morbidity and mortality in both hospital and long term nursing homes as well as in family environments. The direct and indirect cost of AD has been conservatively estimated at 149 billion in the U.S. Medicare expen ...