Award Data

The goal of this project is to design, build, and test an active electromagnetic induction (EMI) sensor array for detecting and characterizing IEDs. At low frequencies (below a few kHz), an EMI sensor is a magnetometer that primarily responds to susceptibility targets (i.e., ferrous objects). The main difference is that, while a magnetometer uses the earth’s field as the illuminating source, an ...

Long-duration wide-area surveillance missions increasingly are space-based. MEO orbits offer space-based radar systems more time on station, but require very large array apertures on the order of 100m in diameter. Achieving larger apertures with smaller, lighter launch packages and stable on-orbit pointing is a challenge that E-Textiles promises to meet. Textile processes can be used to achieve a ...

DESCRIPTION (provided by applicant): This proposal intends to advance the regional delivery of a chimeric adeno-associated virus (rAAV)-based, highly-truncated dystrophin (minidystrophin) gene therapy for the treatment of Duchenes Muscular Dystrophy (DMD). Experiments focus on completing preclinical studies required to initiate, the also proposed, FDA recommended Phase Ib bridging study. The prop ...

DESCRIPTION (provided by applicant): Congestive heart failure is a major cause of morbidity and mortality in the United States. While progress in conventional treatments is making steady and incremental gains to reduce heart failure mortality, there is a critical need to explore new therapeutic approaches. It is now apparent that gene therapy has broader potential in diseases such as congestive he ...

DESCRIPTION (provided by applicant): Traumatic brain injury (TBI), principally as a result of impaction on the intact closed skull, occurs in vehicular incidents, falls, acts of violence, and sports accidents. TBI is the leading cause of death and disability in the United States, with an annual incidence rate of 1.5 million. Of these, 50,000 die acutely, over 230,000 are hospitalized, and 80,000 ...

DESCRIPTION (provided by applicant): Problematic peer relations, particularly when chronic, can have a tremendous impact on children's functioning and mental health. Decades of research indicate that peer rejection, isolation, and victimization negatively impact adjustment and place children at increased risk for a myriad of later negative outcomes. Prevention and treatment research supports the ...

DESCRIPTION (provided by applicant): Growth factors are potent signaling molecules, initiating essential cellular programs for differentiation, proliferation and survival. Only recently have large molecules like growth factors, been employed to enhance the efficacy and specificity of medical implant therapies. In particular, procedures that require native tissues to interact with an implanted mat ...

DESCRIPTION provided by applicant Burn injuries and chronic wounds present a significant burden to patients and the US healthcare system Each year in the US there are burns that require medical treatment and burn patients that require hospitalization The mortality rate associated with severe burns can be as high as with of patient deaths arising from infection In add ...

Based on our successful Phase I effort, Corvid Technologies is pleased to offer this proposal for the development of a first-principles numerical approach to modeling Solid Rocket Motor (SRM) response to unplanned thermal stimuli. We will implement the models identified in Phase I into our unified Lagrangian finite element solver Velodyne to solve the physics associated with cook-off in propellan ...

DESCRIPTION (provided by applicant): Image segmentation is a commonly performed clinical practice for extracting geometrical descriptions of internal anatomical objects from volume images such as computed tomography and magnetic resonance images. Shortcomings of current practice have motivated an important area of research involving statistically trainable deformable-shape models (DSMs) for automa ...