Award Data

DESCRIPTION (provided by applicant): Hemorrhagic fever viruses are of serious worldwide health concern as well as potential biological weapons. Lassa fever virus in particular annually infects several hundred thousand individuals in West Africa, and the export of this pathogen outside of this region, either intentionally or unintentionally, presents a serious risk to the developed countries of the ...

DESCRIPTION (provided by applicant): Concern over the use of variola virus as a biological weapon has prompted interest in development of small molecule therapeutics for smallpox. Variola virus is highly transmissible and causes severe disease with high mortality rates. Currently, there is no FDA-approved drug for prevention or treatment of smallpox. The overall goal of this smallpox antiviral pro ...

Long-duration wide-area surveillance missions increasingly are space-based. MEO orbits offer space-based radar systems more time on station, but require very large array apertures on the order of 100m in diameter. Achieving larger apertures with smaller, lighter launch packages and stable on-orbit pointing is a challenge that E-Textiles promises to meet. Textile processes can be used to achieve a ...

Expansion of the Advanced Breakwater And Causeway Ultramarine System (ABACUS) research and development work accomplished under the Phase II Basic and Options 1 & 2 programs to full scale prototype systems and large scale demonstration models for both Seabasing and ship-to-shore logistics support operations. The ABACUS family of systems support a) the mitigation of waves about Sealift ships at the ...

DESCRIPTION provided by applicant The worldwide health problem created by malaria has been made more difficult by the spread of drug resistant parasites We have developed an orally available and inexpensive class of novel drugs that act against both chloroquine resistant and chloroquine sensitive malaria This project carries on preclinical development of a drug candidate that has been select ...

DESCRIPTION The ultimate goal of this project is to develop an immunotherapy for human immunodeficiency virus HIV based on a spread deficient cytomegalovirus CMV derived vaccine expressing andquot tailoredandquot antigens designed for maximal coverage of clade B epitopes In non human primate models rhesus CMV vectored vaccines demonstrated unprecedented protection against highly virulent ...

Our solution is a generic "gateway/edge translation product", for Secure Legacy Application Integration with the NCES Enterprise Network structure (called “SLAIN”), that provides a modular implementation of the following capabilities to enhance Legacy systems and enable them to interact in a more Net-Centric role in support of the Navy and FORCEnet guidance: • IA interoperability (few legacy ...

DESCRIPTION (provided by applicant): Project Summary/Abstract Treatment of acute ischemic stroke (AIS) with the thrombolytic/antithrombotic agent tissue plasminogen activator (tPA, Activase(R)) is limited due to the potential for severe hemorrhagic side effects. The first symptoms of acute ischemia to tPA treatment ( time to needle ) can span hours, even in developed urban areas, since an establis ...

DESCRIPTION provided by applicant Project Summary Abstract Treatment of acute ischemic stroke AIS with the thrombolytic antithrombotic agent tissue plasminogen activator tPA Activase is limited due to the potential for severe hemorrhagic side effects The first symptoms of acute ischemia to tPA treatment andquot time to needleandquot can span hours even in developed urban areas since ...

To enable warfighters the ability to track entities buried in urban clutter, a series of environmentally-friendly, covert microtaggants composed of nanocrystals functionalized with luminophores with well-defined visible (VIS), near-infrared (NIR) and/or shortwavelength-infrared (SWIR) emission spectra will be further developed. The microtaggant’s quantum-confined nanocrystals are sensitive to on ...