Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

There is growing interest in computerized systems to increase accessibility of assessments for students with disabilities. Technology offers an ideal platform for implementing Universal Design (UD) principles for assessment to better accommodate student diversity and support broad student participation. The goal of this Phase II SBIR project is to continue the research and development of Assess2Pr ...

People who work in the marine sciences field often need to analyze the transmission of sound through the ocean. Today, there are more than 60 different propagation loss models available; no single model is the best in all cases. Choosing the appropriate model, as well as the necessary input data to the model can be a daunting task. In this proposal, we discuss an approach to designing a compute ...

DESCRIPTION (provided by applicant): Adaptation and adoption of evidence based mental health strategies has been challenging for those working with subpopulations disproportionately affected by the aftermath of natural disasters and may contribute to the g rowing racial disparities seen in access to mental health services, diagnosis, and treatment of mental health conditions. Outside assistance te ...

Children with high-functioning autism spectrum disorders (HFX-ASD) are at heightened risk for a wide range of social relationship problems. Specialists in the field of autism suggest the social skill deficits experienced by people with HFX-ASD are the most difficult aspect of the disorder to overcome. This Phase II project will continue the research and development (RandD) of an innovative social ...

During Phase I, Vadum developed a novel combination of lossless predictors and compression techniques that successfully increased compression on a government furnished telemetry data stream and demonstrated that even greater compression was achievable on the video stream. In Phase II, Vadum proposes to implement an In-Line Compression Solution (ICS) that delivers robust, high rate compression wit ...

The mitigation of mainlobe jamming is essential to missile defense radar performance. Applied Radar is currently investigating distributed aperture and adaptive processing architectures that promise a new generation of advanced radar performance. Our proposed program will research the application of these distributed aperture radar techniques to determine the mainlobe jammer suppression possible w ...

ABSTRACT: The effectiveness of adaptive training systems has been repeatedly demonstrated. However, to foster widespread adoption, tools are needed to reduce the level of effort and cost associated with development and sustainment. To respond to this challenge, Sonalysts proposes to develop the Rapid Adaptive Coaching Environment (RACE). Using a guided authoring and maintenance approach, RACE ...

There is an ongoing requirement to reduce the cost and time associated with insulation attachment during outfitting and new construction on naval vessels. Currently, the primary method of attaching insulation on metal surfaces is through the used of welded studs. These studs are attached to decks and bulkheads early in the construction process and are often damaged before the construction process ...