Award Data

DESCRIPTION provided by applicant This SBIR Phase I proposal is intended to demonstrate the feasibility of developing a novel and effective therapeutic agent for acute radiation injury The threat of nuclear terrorism remains high and there is a possibility of a nuclear power plant leak both of which can cause acute radiation injury at a large scale Currently there are no therapeutic agents ...

As supercomputing speeds increase and storage costs drop, scientists running applications in various disci- plines, such as high-energy physics, genomics, climate studies, etc., generate datasets of ever-increasing sizes at distributed locations around the world. Backbone Research-and-Education Network (REN) providers such as DOEs Energy Sciences Network (ESnet) and Internet2, provide high-speed, ...

DESCRIPTION provided by applicant Nearly percent of death and disease worldwide is linked to environmental factors WHO therefore it is critical that the general public has basic understanding of how the environment affects their health and how they might protect themselves against environmental exposures Unfortunately environmental health content is typically covered on a very ...

DESCRIPTION provided by applicant Sanfilippo disease mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which plays importa ...

DESCRIPTION provided by applicant Hematopoietic stem cell transplantation is a form of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood related diseases However there currently are several drawbacks in the use of bone marrow hematopoietic cell transplantation Most importantly the donor pool is limited by the need for at least partial HLA matching and t ...

DESCRIPTION provided by applicant The goal of this project is address a large unmet medical need by providing more kidneys for transplant For the andgt patients with end stage renal disease in the U S the pool of cadaveric kidneys has remained stagnant over the past decade As a result the dialysis population is expected to reach andgt million patients in the next decade at an aggr ...

DESCRIPTION provided by applicant The ultimate objective of this program is to develop a novel therapeutic approach that will save lives of patients with stroke Acute stroke is the third leading cause of death in the United States and the primary medical cause of acquired adult disability Each year Americans experience new or recurrent stroke It accounts for out of every death ...

DESCRIPTION provided by applicant The pre fusion conformation of the RSV F protein preF is the primary determinant of neutralization in immunized sera However this conformation is unstable and rapidly transitions to the postfusion conformation A disulfide stabilized prefusion variant with cavity filling mutations DS Cav has been shown to yield high neutralizing titers in animals howeve ...

DESCRIPTION provided by applicant Current seasonal Influenza vaccines are proving to be ineffective especially in at risk populations For example this yearandapos s inactivated flu vaccine had only a efficacy rate against H N infections in the elderly and the current live attenuated Influenza vaccine LAIV is aged restricted for those above years of age Therefore there is glaring un ...

DESCRIPTION provided by applicant Babesia microti the primary etiologic agent of human babesiosis is a tick borne eukaryotic apicomplexan pathogen that is an increasing threat to the US public health Although B microti is primarily a tick borne pathogen it can be transmitted by transfusion of infected blood Despite the well recognized threat there is no FDA licensed test to screen donor ...