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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Clinical Human Cell Production System for Broad Use

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

    SBIR Phase I 2003 Department of Health and Human Services
  2. Enhanced Tumor Antigen Priming of Dendritic Cell Vaccine

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

    SBIR Phase I 2003 Department of Health and Human Services
  3. Automated Perfused Culture Process for Adult Stem Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

    SBIR Phase I 2003 Department of Health and Human Services
  4. Clinical-scale Production of Osteoprogenitor Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

    SBIR Phase I 2003 Department of Health and Human Services
  5. Automated Large-Scale Production of Endothelial Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

    SBIR Phase I 2003 Department of Health and Human Services
  6. Personal Monitor to Detect Exposure to Toxic Agents

    SBC: ADVANCED SENSOR TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Advanced Sensor Technologies, Inc. (AST) proposes to continue its NIH funded Phase I efforts to develop a completely automated miniaturized device capable of monitoring different types of cholinesterases from a single drop of whole blood to determine the degree of exposure of an individual to organophosphate (OP) compounds or carbamates. This device will be ame ...

    SBIR Phase II 2003 Department of Health and Human Services
  7. Real-Time Melatonin Monitor to Diagnose Sleep Disorder

    SBC: ADVANCED SENSOR TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): With an ever-growing elderly population, it is becoming increasingly important to monitor physiological correlates associated with age. One major problem associated with age revolves around quantity and quality of sleep. Many commercial devices monitor physiometric nocturnal activity (i.e. actigraphy, EEG, EMG, EOG, respiration, etc.), however, there are no co ...

    SBIR Phase II 2003 Department of Health and Human Services
  8. Study of Peripheral Immune Effects and Pathway on Brain

    SBC: ADVANCED SENSOR TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There exists a growing body of evidence, both experimental and clinical, which supports the concept of intimate communication between the central nervous and immune systems to maintain homeostasis and health. Data support the fact that this interrelationship is bi-directional, such that the immune system is subject to regulation by neuroendocrine factors and vi ...

    SBIR Phase I 2003 Department of Health and Human Services
  9. Real-Time Melatonin Monitor to Diagnose Sleep Disorder

    SBC: ADVANCED SENSOR TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): With an ever-growing elderly population, it is becoming increasingly important to monitor physiological correlates associated with age. One major problem associated with age revolves around quantity and quality of sleep. Many commercial devices monitor physiometric nocturnal activity (i.e. actigraphy, EEG, EMG, EOG, respiration, etc.), however, there are no co ...

    SBIR Phase I 2003 Department of Health and Human Services
  10. Anthropomorphic Loading Device for Seat Cushion Testing

    SBC: BENEFICIAL DESIGNS INC            Topic: N/A

    DESCRIPTION (provided by applicant): The ability to evaluate the performance of seat cushions is critical to the development of wheelchair seating and standards, and to the selection of cushions by consumers and therapists. To assess the ability of a wheelchair cushion to distribute pressure, the Skeletal Embedded Loading Indentor (SKELI) was designed to simulate both the soft tissue and bony skel ...

    SBIR Phase I 2003 Department of Health and Human Services

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