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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ARBUS, INC.

    SBC: Arbus, Inc.            Topic: N/A

    ARBUS, INC., WILL EXPLORE THE FEASIBILITY OF, AND SUBSEQUENTLY DEVELOP, A COMPUTERIZED PHARMACEUTICAL TRACKING SYSTEM FOR INVESTIGATIONAL DOSAGE FORMS. DURING PHASE I, ARBUS PERSONNEL WILL FULLY DEFINE WHAT PRODUCT DOCUMENTATION IS REQUIRED AND WHAT METHOD IS PREFERRED FOR THE SYSTEM USERS TO INTERACT WITH THE PROPOSED SYSTEM. KEY DEVELOPMENT DOCUMENTATION WILL BE DRAFTED CLARIFYING THE COMPUTER H ...

    SBIR Phase I 1985 Department of Health and Human Services
  2. CARDIAC OUTPUT MONITORING BY CO2 REBREATHING

    SBC: Axon Medical Inc            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  3. URINARY TRACT INFECTIONS ASSOCIATED WITH URINARY DRAINAGE CATHETERS ARE A SIGNIFICANT CLINICAL PROBLEM RESULTING IN A PROLONGED HOSPITAL STAY AND AN INCREASED MORTALITY RISK.

    SBC: Biomaterials International Inc            Topic: N/A

    URINARY TRACT INFECTIONS ASSOCIATED WITH URINARY DRAINAGE CATHETERS ARE A SIGNIFICANT CLINICAL PROBLEM RESULTING IN A PROLONGED HOSPITAL STAY AND AN INCREASED MORTALITY RISK. THIS PROPOSAL ADDRESSES A FEASIBILITY STUDY TO DETERMINE IF SURFACE MODIFICATION OF THE CATHETER WILL INHIBIT BACTERIAL MIGRATION. THE PROPOSED RESEARCH WILL TEST THE HYPOTHESIS THAT BACTERIAL FIVE DIFFERENT SURFACE TREATMENT ...

    SBIR Phase I 1985 Department of Health and Human Services
  4. A TREATMENT OF HYDROPHILIC POLY(HYDROXYETHYL METHACRYLATE) CONTACT LENSES TO MINIMIZE IRREVERSIBLE PROTEIN ADSORPTION WILL BE TESTED.

    SBC: Biomaterials International Inc            Topic: N/A

    A TREATMENT OF HYDROPHILIC POLY(HYDROXYETHYL METHACRYLATE) CONTACT LENSES TO MINIMIZE IRREVERSIBLE PROTEIN ADSORPTION WILL BE TESTED. PROTEIN ADSORPTION ON LENSES NOT ONLY LEADS TO CLOUDING AND OPACITIES, BUT ALSO INDUCES WHAT APPEARS TO BE AN IMMUNE RESPONSE IN THE WEARER. THIS RESPONSE IS OBSERVED IN THE EARLY STAGES TO INCLUDE INCREASED MUCUS PRODUCTION, MILD ITCHING, DECREASED LENS TOLERANCE A ...

    SBIR Phase I 1985 Department of Health and Human Services
  5. SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN

    SBC: Biomaterials International Inc            Topic: N/A

    SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN (ANTIGEN-ANTIBODY COMPLEX) FROM THE PATIENT'S PLASMA AND RETURN HIS/HER OWN PURIFIED PLASMA TO THE PATIENT. THE FIRST PHASE OF THE PROPOSED WORK IN ...

    SBIR Phase I 1985 Department of Health and Human Services
  6. A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS FOR THE DETECTION OF PATHOGENIC VIRUSES, BACTERIA, AND CELLS.

    SBC: Biomaterials International Inc            Topic: N/A

    A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS FOR THE DETECTION OF PATHOGENIC VIRUSES, BACTERIA, AND CELLS. DEVELOPMENT OF AN INTERFACIAL LIGHT-SCATTERING IMMUNOASSAY (ISI) IS PROPOSED. SURFACE IMMOBILIZED ANTIBODIES PROVIDE TARGET ORGANISM SPECIFICITY WHILE TOTAL INTERNAL REFLECTION-GENERATED INTERFACIAL LIGHT SCATTERING PROVIDES INTENSE, TARGET-SPECIFIC SIGNAL. S ...

    SBIR Phase I 1985 Department of Health and Human Services
  7. RAMAN SCATTERING FOR CLINICAL GAS DIAGNOSIS

    SBC: Biomaterials International Inc            Topic: N/A

    N/A

    SBIR Phase I 1985 Department of Health and Human Services
  8. BSD CORPORATION HAS BEGUN DEVELOPMENT OF A REGIONAL HYPERTHERMIA HEATING APPLICATOR WHICH HAS BEEN GIVEN THE NAME ""THIN-SHELL ANNULAR PHASE ARRAY.

    SBC: Bsd Medical Corp.            Topic: N/A

    BSD CORPORATION HAS BEGUN DEVELOPMENT OF A REGIONAL HYPERTHERMIA HEATING APPLICATOR WHICH HAS BEEN GIVEN THE NAME ""THIN-SHELL ANNULAR PHASE ARRAY.'' THE DEVICE IS AN ANNULAR RADIOFREQUENCY ANTENNA WHICH RADIATES POWER MOSTLY INTO ITS ANNULUS. ITS DIAMETER CAN BE OF THE ORDER OF 50 CM AND ITS WALL THICKNESS CAN BE ONLY A FEW CENTIMETERS. THUS IT CAN BE PLACED IN THE ANNULUS OF A CT SCANNER. BSD WI ...

    SBIR Phase I 1985 Department of Health and Human Services
  9. "CULTURING AMPHIBIANS FOR BIOMEDICAL RESEARCH"

    SBC: Central Valley Biological Inc            Topic: N/A

    LARGE NUMBERS OF RESEARCH QUALITY AMPHIBIANS ARE NEEDED ANNUALLY FOR BIOMEDICAL RESEARCH. CURRENTLY, THERE ARE SEASONAL SHORTAGES AND INCONSISTENT SUPPLY OF THE BULLFROG, RANA CATESBIANA AND AXOLOTL, AMBYSTOMA MEXICANUM. THROUGH TEMPERATURE MANIPULATION AND HORMONAL INJECTION IT WILL BE SHOWN THAT THESE AMPHIBIANS CAN NOT ONLY BE CULTURED AND CONDITIONED IN CAPTIVITY TO THE EXTEND NEEDED, BUT THAT ...

    SBIR Phase II 1985 Department of Health and Human Services
  10. CHRONIC PROGRESSIVE HEART FAILURE WILL BE PRODUCED IN SHEEP BY ADMINISTRATION OF SPECIFIC MYOCARDIOTOXIC DRUGS.

    SBC: Deseret Research Company Inc            Topic: N/A

    CHRONIC PROGRESSIVE HEART FAILURE WILL BE PRODUCED IN SHEEP BY ADMINISTRATION OF SPECIFIC MYOCARDIOTOXIC DRUGS. IN PHASE I, PROJECT FEASIBILITY WILL BE DETERMINED BY ADMINISTERING ALLYLAMINE, DOXORUBRICIN, OR COBALT CHLORIDE IN VARYING DOSES TO HEALTHY SHEEP, THEN FOLLOWING CHANGES WHICH OCCUR WITH TIME IN CARDIAC OUTPUT, HEMODYNAMICS IN THE GREAT VESSELS AND ALL FOUR CHAMBERS OF THE HEART, AND LE ...

    SBIR Phase I 1985 Department of Health and Human Services

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