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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. High Performance Energetic Propellant Ingredient Process Research and Development


    CL-20 is the most powerful conventional explosive known, but its high cost has limited its adoption in a range of potential applications. Par of the challenge in making these materials is the complexity of the reaction used to prepare the polycyclic cage. The complexity of this reaction makes it difficult to have insight into the reaction and to improve it. Additionally, several of the intermediat ...

    STTR Phase II 2017 Department of DefenseNavy
  2. Reduced Cost, Repeatable, Improved Property Washout Tooling for Composite Fabrication

    SBC: Nevada Composites, Inc.            Topic: N16AT015

    Nevada Composites has developed Green-Aero(sm) toolinglightweight ceramic tooling that is stable under high pressure and long-duration cure cycles and can be washed out with water after cures to 370C (700F). Tools, whether single-sided or washout, have a composite-compatible CTE, provide tight tolerances, are reproducible, are stable to storage under ambient conditions, and are of affordable cost. ...

    STTR Phase II 2017 Department of DefenseNavy
  3. Fast and Flexible Differential Equation Model Fitting with Application to Pharmacometrics

    SBC: Metrum Research Group LLC            Topic: N16AT016

    We are developing a platform for pharmacometric data analysis workflow that is much more flexible and efficient than anything else on the market. This will be accomplished by (1) developing new functions within Stan, a widely used, open-source, probabilistic programming language and Bayesian inference engine, for computationally efficient data analysis using complex differential equation models, ( ...

    STTR Phase II 2017 Department of DefenseNavy
  4. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Production of Chemical Reagents for Prompt-Agent-Defeat Weapons


    Nalas Engineering and Johns Hopkins University collaborated in a Phase I STTR program to study reactive mixtures of HI3O8 and nanocomposite fuels previously developed by the Weihs Group. These fuel/oxidizer mixtures are uniquely able to simultaneously produce heat and biocidal iodine gas, a combination designed to destroy biological weapons. The team at Nalas focused on evaluating conditions for p ...

    STTR Phase II 2017 Department of DefenseDefense Threat Reduction Agency
  6. Relevant Image Mosaic Image Management Algorithm Development

    SBC: SONALYSTS, INC.            Topic: N172112

    Current Naval Air Systems imagery exploitation systems are fed new images from high speed data streams but have limited organic system file storage capability. With no built in logic to manage the storage volume, a first-in-first-out default overwrite situation often results, which hampers mission planning or results in planners having to expend time manually searching external libraries for neede ...

    SBIR Phase I 2017 Department of DefenseNavy
  7. Gamification for Combat System Employment

    SBC: SONALYSTS, INC.            Topic: N171035

    Surface ship ASW personnel will go for long stretches at sea without conducting ASW operations, which results in skill degradation. The Navy has embedded training in operational systems for decades but has never closed the loop between the training and operator performance. In order to address this need, Sonalysts, Inc. proposes to develop an innovative Gamification Training Architecture (GTA). Th ...

    SBIR Phase I 2017 Department of DefenseNavy
  8. Development of TP for the Induction and Maintenance of Remission in Ulcerative Colitis Patients

    SBC: Thetis Pharmaceuticals LLC            Topic: 300

    ABSTRACT Thetis plans to investigate TP an innovative and potential first in class therapeutic agent as an oral therapy for the induction and maintenance of remission of intestinal inflammation symptoms in ulcerative colitis UC patients While the precise etiology of UC is unknown it is thought to result from an inappropriate inflammatory response to commensal gut bacteria in genetically ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Novel diagnostics for autoimmunity from checkpoint inhibitor immune therapy

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIDDK

    Checkpoint inhibitor CPI therapy has transformed treatment of solid tumors Clinical responses in the range of with prolonged survival have been reported for tumors such as malignant melanoma and non small cell lung cancer that previously had poor response rates and dismal prognoses Current therapies block PD PD L and CTLA and there are other targets being developed such as LA ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Hemostatic Agent Development

    SBC: HYBRID PLASTICS            Topic: N101085

    The proposed effort aims to increase the TRL of the hemostatic agent through completion of relevant animal and toxicological research and development. These advancements will be verified through process improvements to meet good manufacturing practices. A series of registration approvals for the device along with packaging requirements will be advanced. Additional efficacy and competitive per ...

    SBIR Phase II 2017 Department of DefenseDefense Health Program

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