Award Data

The purpose of this proposal is to develop a validated physiological model of the human physiologyespecially the cardio renal axisfor submission to the FDA Medical Device Development Tool pilot programThe model will be used to aid in the development and regulation of medical devices designed to treat hypertensionExamples include devices for renal nerve ablationelectrical stimulation of the carotid ...

NASA has long used liquid hydrogen as a fuel and plans to continue using it in association with their advanced nuclear thermal propulsion technology. Hydrogen fire detection is critical for rocket propulsion safety and maintenance. A significant fire at a rocket test or launch facility could be catastrophic to infrastructure or even worse, to human life. Detection monitoring is problematic as hydr ...

Project Summary Abuse of prescription opioids and fatalities related to their misuse have increased sharply in recent yearsmaking the development of pain medications with reduced abuse potential a major public health priorityWhen combinedopioids and cannabinoidCBreceptor agonists show analgesic effects appear to be at least additive in a number of pain modelsCannabidiolCBDalthough much less psycho ...

SciGenesis intends to optimize its novel flame-retardant (FR) technology that is specific for 50/50 NYCO fibers for the Marine Corp. Combat Uniform (MCCUU) by engineering unique application methods which will provide FR protection for future and current Marine Corp. uniforms. Initial considerations for application will focus on (A) padding the textile after camouflage patterning, as well as (B) ap ...

ARBUS, INC., WILL EXPLORE THE FEASIBILITY OF, AND SUBSEQUENTLY DEVELOP, A COMPUTERIZED PHARMACEUTICAL TRACKING SYSTEM FOR INVESTIGATIONAL DOSAGE FORMS. DURING PHASE I, ARBUS PERSONNEL WILL FULLY DEFINE WHAT PRODUCT DOCUMENTATION IS REQUIRED AND WHAT METHOD IS PREFERRED FOR THE SYSTEM USERS TO INTERACT WITH THE PROPOSED SYSTEM. KEY DEVELOPMENT DOCUMENTATION WILL BE DRAFTED CLARIFYING THE COMPUTER H ...

Heavy alcohol use is commonyet avoidable cause of deathdisability and human sufferingThese adverse outcomes are potentially avoidable if heavy alcohol use is spotted earlyHowevercurrent screening methods for chronic alcohol consumption capture alcohol usage only in the hours prior to testing or rely on insensitivenon specific protein assaysIn a recent highly successful Phase II projectusing DNA fr ...

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Non-technical SummaryCurrently, there are no efficacious vaccines to protect piglets against disease caused by the emerging zoonotic (transmissible from animals to humans) pathogen, Streptococcus suis. Porcine S. suis disease is a major cause of morbidity and mortality in weaned piglets and is a significant economic burden on pork producers globally. Losses to the pig industry globally are in the ...

Tuna ranching is dependent on wild-captured fish and the current operational model is largely unsustainable as it increases fishing pressure on the Pacific bluefin tuna (PBFT) wild stock. Recent ISC (International Scientific Committee for Tuna and Tuna-like Species in the North Pacific Ocean) assessments indicate that this stock is "alarmingly overfished", while experiencing high exploitation rate ...

This Small Business Technology Transfer (STTR) Phase I effort will demonstrate the feasibility of using piezoelectric fibers to detect shock waves from underwater explosions (UNDEX) and sensing physiological measures such as heart and respiratory rates on warfighters. Piezoelectric fibers will be characterized for their ability so sense different amplitudes and frequencies of shock and vibration. ...