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The purpose of this proposal is to develop a validated physiological model of the human physiologyespecially the cardio renal axisfor submission to the FDA Medical Device Development Tool pilot programThe model will be used to aid in the development and regulation of medical devices designed to treat hypertensionExamples include devices for renal nerve ablationelectrical stimulation of the carotid ...

NASA has long used liquid hydrogen as a fuel and plans to continue using it in association with their advanced nuclear thermal propulsion technology. Hydrogen fire detection is critical for rocket propulsion safety and maintenance. A significant fire at a rocket test or launch facility could be catastrophic to infrastructure or even worse, to human life. Detection monitoring is problematic as hydr ...

Project Summary Abuse of prescription opioids and fatalities related to their misuse have increased sharply in recent yearsmaking the development of pain medications with reduced abuse potential a major public health priorityWhen combinedopioids and cannabinoidCBreceptor agonists show analgesic effects appear to be at least additive in a number of pain modelsCannabidiolCBDalthough much less psycho ...

SciGenesis intends to optimize its novel flame-retardant (FR) technology that is specific for 50/50 NYCO fibers for the Marine Corp. Combat Uniform (MCCUU) by engineering unique application methods which will provide FR protection for future and current Marine Corp. uniforms. Initial considerations for application will focus on (A) padding the textile after camouflage patterning, as well as (B) ap ...

ARBUS, INC., WILL EXPLORE THE FEASIBILITY OF, AND SUBSEQUENTLY DEVELOP, A COMPUTERIZED PHARMACEUTICAL TRACKING SYSTEM FOR INVESTIGATIONAL DOSAGE FORMS. DURING PHASE I, ARBUS PERSONNEL WILL FULLY DEFINE WHAT PRODUCT DOCUMENTATION IS REQUIRED AND WHAT METHOD IS PREFERRED FOR THE SYSTEM USERS TO INTERACT WITH THE PROPOSED SYSTEM. KEY DEVELOPMENT DOCUMENTATION WILL BE DRAFTED CLARIFYING THE COMPUTER H ...

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This Small Business Technology Transfer (STTR) Phase I effort will demonstrate the feasibility of using piezoelectric fibers to detect shock waves from underwater explosions (UNDEX) and sensing physiological measures such as heart and respiratory rates on warfighters. Piezoelectric fibers will be characterized for their ability so sense different amplitudes and frequencies of shock and vibration. ...

ADVANCED COMPOSITES HAVE POTENTIAL FOR EFFECTING WEIGHT SAVINGS AND PROVIDING CORROSION RESISTANCE TO A VARIETY OF MILTARY APPLICATIONS. THE MK112 ASROC LAUCHER MODS 1-8 AND GUIDE, ES114, HAVE BEEN IDENTIFIED AS HAVING EXPERINECED CORROSION AND WEIGHT PROBLEMS. THERE ARE A VARIETY OF RESINS AND FIBERS AVAILABLE FOR USE AS STRUCTURAL MATERIALS THESE INCLUDE GLASS, KEVLAR & CARBON FIBERS,AND POLYEST ...

STUDIES IN THIS PROPOSAL WILL BE AIMED AT THE PREPARATION OFA SUPPOSITORY FORMULATION OF A PRO-DRUG OF DELTA-9-TETRA- HYDROCANNABINOL (^9-THC) AND STUDY THE BIOAVAILABILITY OF THC FROM THIS FORMULATION AS COMPARED TO I.V. ADMINISTRATIONOF BOTH THC AND ITS PRODRUG. BIOAVAILABILITY STUDIES WILL BE CONDUCTED IN MONKEYS, AND BLOOD SAMPLES WILL BE COLLECTEDAT 0, 15, 30, 60, 90, 120, 180, 240, AND 480 M ...

FOR A USER TO ORDER SATELLITE IMAGE DATA SETS FROM THE NATIONAL CLIMATIC DATA CENTER INTELLIGENTLY AND RELIABLY, HEMUST VERIFY THAT THE DATA SET COVERS HIS REGION OF INTEREST AND IS FREE ENOUGH FROM CLOUD COVER TO BE USEABLE. TO SOLVETHIS PROBLEM, WE PROPOSE TO DEVELOP IBM PERSONAL COMPUTER COMMUNICATIONS SOFTWARE WHICH INTERFACES TO AN INEXPENSIVE GRAPHICS BOARD TO DISPLAY SATELLITE ORBITS ON A M ...