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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Boron-containing antimalarial drug discovery

    SBC: REACTIVE BIOSCIENCES INC            Topic: NIAID

    PROJECT SUMMARY New drugs to treat malaria, ideally with unique chemical structures and mechanisms of action, are urgently needed. Optimal drug candidates for the treatment and prevention of malaria will have potent activity against cultured parasites and in animal models of malaria, be rapidly active against erythrocytic malaria parasites, be orally bioavailable, have extended pharmacological exp ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Novel Oral Antibiotic for the Treatment of Drug Resistant Gonorrhea

    SBC: AIMMAX THERAPEUTICS INC            Topic: NIAID

    PROJECT SUMMARY / ABSTRACT The CDC has identified Neisseria gonorrhoeae as a pathogen of the highest threat level (“Urgent Threat”) to the US public health. Currently there is only a single recommended agent remaining on the CDC treatment guidelines, an intramuscular injection of the extended spectrum cephalosporin, ceftriaxone. However, in the past decade, reports of resistance to ceftriaxone ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Commercializing CivaSheet for Pancreatic Cancer Patients

    SBC: CIVATECH ONCOLOGY INC            Topic: NCI

    CivaTech Oncology’s mission is to provide improved radiation therapy directly to diseased tissues while sparing healthy tissues. With NIH/NCI SBIR support, the Company has eliminated local recurrence of disease in pancreatic cancer patients – a huge success. Pancreatic cancer is predicted to soon become the most commonly diagnosed cancer in the US and there are no significant, impactful therap ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid and robust assay for measurement of in vivo activity of chromatin-interacting proteins

    SBC: Epicypher, Inc.            Topic: NIAID

    PROJECT SUMMARYThe activity of chromatin-associating proteins (CAPs) is fundamental to regulation of gene expression. Elucidating CAP activity is central to understanding the regulatory mechanisms that drive cell biology, both in the context of health and disease, and to guide development of novel therapeutics. However, this work is not straightforward, as CAP activity is regulated by multiple fac ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. GMP manufacturing and IND Filing of IN-002, a potent inhaled muco-trapping antibody therapy for Respiratory Syncytial Virus

    SBC: Inhalon Biopharma Inc            Topic: NIAID

    Title: GMP manufacturing and IND Filing of IN-002, a potent inhaled “muco-trapping” antibody therapy for Respiratory Syncytial Virus Project Summary (30 line limit) Respiratory Syncytial Virus (RSV) is the leading cause of viral hospitalization and death in infants and young children and is also a major cause of respiratory illness in immune compromised adults and the elderly. Unfortunately, t ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Clinical Development Enablement – Long Term Rodent Testing of the Carcinogenic Potential of the Alzheimer’s Disease Drug Candidate T3D-959

    SBC: T3D Therapeutics, Inc.            Topic: NIA

    T3D-959 is a new chemical entity, orally delivered, small molecule, dual nuclear receptor agonist aimed at improving dysfunctional brain glucose energy and lipid metabolism in Alzheimer’s disease (AD), it is non- amyloid/non-tau-directed. Metabolic homeostasis, inherently altered in AD, leads to protein misfolding resulting in plaque formation, tangle formation and inflammation. Exploratory huma ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Development of ultra-efficient antibodies for single cell mapping applications

    SBC: Epicypher, Inc.            Topic: NIAID

    PROJECT SUMMARYHistone post-translational modifications (PTMs) are some of the most widely studied epigenomic factors, and alterations in histone PTM abundance / distribution have been implicated in numerous disease etiologies. Epigenomic mapping of histone PTMs in limited cell populations or single cells (SCs) would provide the opportunity to study the epigenetic landscape of rare and heterogenou ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality: Administrative Supplement

    SBC: ISTOSVISIO INC            Topic: 101

    The original Phase IIb proposal addressed problems in analyzing, accessing and communicating increasingly large 3D and 4D image sets in neuroscience. This supplement request is motivated by two unforeseen developments since submission and review of the original application. The requested activities are necessary to maintain the high overall impact of the project. First, due to larger than expected ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. High-throughput injectability screening of high concentration protein formulations by microfluidic quartz resonators

    SBC: QATCH TECHNOLOGIES LLC            Topic: 400

    The objective of this SBIR Direct Phase II proposal is to carry QATCH’s nanovisQ™ technology, which is a wide-shear-rate range and low volume viscometer for determining developability and injectability of biopharmaceutical formulations, from single-test sensors to high-throughput and automated format. This objective is motivated by the needs of the growing protein-based biopharmaceutical thera ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. CN-105 Improves Functional Outcome After Intracranial Hemorrhage

    SBC: AegisCN LLC            Topic: 106

    Annually, approximately 100,000 patients in the USA suffer from intracerebral hemorrhage (ICH), which is associated with high mortality rates and poor long-term cognitive and physical recovery. At present, no pharmacological therapies have been demonstrated to improve functional outcomes after ICH. However, we have successfully demonstrated that CN-105, a pentapeptide derived from the receptor bin ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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