Award Data

PROJECT SUMMARY Nucleosomes are the basic building blocks of chromatin and composed of bp DNA wrapped around a core histone octamer Chromatin function is controlled by the dynamic addition removal of histone post translational modifications PTMs Significantly alterations in specific PTMs are associated with changes in gene expression driving the emergence progression of many cancer ...

Project Summary Abstract DermaXon s project goal is to develop efficacious novel selective inhibitors of CYP A for the topical treatment of ichthyosis Congenital ichthyosis is a family of hereditary disorders of keratinization characterized by dry scaling skin that may be thickened or very thin impacting the quality of life of patients and their family members Currently there is no cure f ...

DESCRIPTION provided by applicant We propose to bring to market a novel regenerative medicine based therapy for fecal incontinence FI FI is the recurrent uncontrolled passage of fecal material The Internal Anal Sphincter IAS is responsible for maintaining anorectal continence Function of the IAS is dependent upon the neuromuscular integrity of both the smooth muscle and the intrinsic en ...

Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

Abstract Neurological conditions such as multiple sclerosis Parkinson s disease dementia spina bifida diabetes stroke and spinal cord injury SCI can result in loss of voluntary voiding of urine and require intermittent bladder catheterization for voiding Catheter use is associated with increased incidence of health problems predominately repeated urinary tract infections sepsis ureth ...

Project Summary Abstract The goal of this proposal is to develop a novel high throughput platform for understanding gene regulatory elements in order to identify new drug targets for common diseases The human genome encodes approximately genes Understanding how those genes are regulated and how this correlates to complex cell phenotypes has long been a major focus of our team Follow up p ...

PROJECT SUMMARY The studies proposed here address a significant health issue the high incidence of acquired deafness from noise overstimulation that can result from recreational and workplace related activities and from service in the military Through a robust academic pharma partnership between investigators at the Kresge Hearing Research Institute with long standing interests and expertise in ...

GTL?s SNS technology aids in the operation of new or existing structural health monitoring (SHM) systems by integrating data and power pathways into the structure. The use of this technology within a composite structure would allow engineers to place sensors from an SHM system directly where they are needed on a structure with instant power. GTL?s SNS technology offers the potential for developers ...

DEC-Shield technology offers the means to generate electric power from cosmic radiation sources and fuse dissimilar systems and functionality into a structural component to create a Multi-functional Structure (MFS). DEC-Shield integrated into MFS technology can be used to generate electric power and provide radiation protection in a space vehicle; even maximizing that protection by spreading the ...

Using novel materials and device geometries unique to North Carolina State University (NCSU) and Third Floor Materials (3FM) this program will develop a detector technology that enables room-temperature multispectral IR imaging by exploring transduction pathways between infra red light and a measureable electric signal mediated by an epsilon-near-zero (ENZ) mode. The research activity will use a c ...