Award Data

Spinal cord injurySCIfrequently produces severelife long bladder and bowel dysfunction that result in urinary and fecal incontinenceas well as sphincter dyssynergia that causes urinary retention and fecal impactionCurrent standard of care for incontinence consists of adult diaperswhile bladder and bowel voiding require multiple times daily catheterization of the bladder and regular digital extract ...

We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and jointsInflammatory arthritis disables thousands of people each yearIt occurs in children and adultsafter trauma and infections but most cases are idiopathicMillions of adults live with chronic RAwhich has similar featuresInflammatory arthritis often requires trea ...

ABSTRACT Uveitisthe most common form of intraocular inflammationaccounts forof preventable blindness in the USTreatment options are limited to cortiscosteroids and or immunosuppressantsbut both of these therapies show limited efficacy and are associated with numerous adverse and potentially serious side effectsNew therapeutic targets leading to effective and safe treatments are urgently requiredA ...

Project SummaryAbstract Rheumatoid arthritisRAis a chronic inflammatory disease in which hyperactivated immune cells induce maladaptive persistent inflammation in the jointsleading to synovial inflammation and bone remodelingIn the USRA currently affects roughlyof the population and carries a total annual societal cost burden of approximately $billionIn RAsustained elevations of pro inflammatory c ...

Infertility is a global health problemand in the USmillion women are treated for infertility every yearThere is a strong need to promote patient friendly methods for progesterone supplementation in assisted reproductive technologyARTIntravaginal rings are well tolerated by womenare efficacious for contraception and hormone replacement therapyhave high patient complianceand are now in development f ...

Abstract The objective of this proposal is to validate a new regenerative tissue matrix which studies to date indicate may be possible of redefining the limits of autologous fat graftingThis objective is motivated by the currently limited surgical options available to themillion patients undergoing reconstructive plastic surgery each year to treat body disfigurement and dysfunctionA core component ...

ABSTRACT Rotator cuff repairRCRis a common first line surgical solution to symptomatic rotator cuff injurywith overRCRs performed annuallyand growing at a rate ofUnfortunatelyof the cases are complicated by failure and re tear of the repaired tendonwhich commonly results in a significant reduction in activities of daily livingworkand or sports and recreation for the patient due to pain and restric ...

The goal of this STTR is to provide a preclinically validated monoclonal antibody or antibody combination for the prevention of respiratory syncytial virusRSVin high risk patients including infants and the elderlyWorldwideof children are infected with RSV before the age ofresulting in an estimatedmillion lower respiratory tract infectionsIn the United States adults overhavemillion RSV infections c ...

Project SummaryAbstract This project will develop and test a publicly available web interface for executing and monitoring genomic data analysis pipelines described by the Workflow Description LanguageThe interface will be hosted on Truwl TMhttpstruwl comxD Bio s TMcommunity oriented genomic data analysis methods sharing web applicationExecuting pipelines will leverage the reproducibility framewor ...

Seventeen million people each year suffer from an ischemic stroke and millions are left dead and disabledTreatment with recombinant tissue plasminogen activatorr tPAis only modestly effective at reducing disability and it is associated with brain hemorrhage in up toof patients when serial imaging studies are performedBrain hemorrhage causes death and disability andis the major cause of early morta ...