Award Data

The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

Thin-ply prepregs offer significant improvements in weight reduction, stiffness and overall mechanical properties over traditional composite laminates. nbsp;Thin plies (lt;0.05 mm/layer) suppress or delay crack initiation in loaded composite structures thereby allowing for manufacturing of lighter, stiffer and more durable composite products. Recent thin-ply prepreg materials, consisting of toughe ...

A new UV imaging polarimeter design was demonstrated by Optical Coating Solutions, Inc. (OCS) as a proof-of-concept breadboard in a 2016 Phase I effort (NASA Contract NNX16CA44P). A version of that generic design is proposed for atmospheric studies in a follow-on effort.nbsp;The new polarimeter design can operate to wavelengths as short as 260nm and does not employ electronic or mechanical modulat ...

Non-destructive evaluation (NDE) using acoustic vibrations is a widely used method to assess unique structures and composite materials. Non-contact forms of ultrasonic NDE, such as laser-induced ultrasound, are particularly suited for in situ evaluation in extreme environments. Current limitations of this method include the inability to identify shadowed defects, probe double-walled vessels, and e ...

Bulk metallic glass (BMG) has gained popularity over the last two decades as alloys have been developed that can remain in a supercooled state at sufficient intervals to allow for processing in a similar manner to plastics. Their physical properties, including an unusual combination of hardness, strength, and elasticity, have made them ideal candidates for the production of strain wave gears. Both ...

Combining both genomic analysis and highEresolution imaging on a cellEbyEcell basis typically relies on customized technology which often requires significant expertise and capital costCell MicrosystemsInchas partnered with Peter SimsPhD of Columbia University to commercialize a novel workflow for integrated imaging and sample preparation for single cell transcriptomic analysisDrSims workflowSingl ...

Under the Small Business Innovation Research ProgramSBIRPhase I programTopicthe Contractor will develop an integrated device and system for drug detection and deactivation to deter controlled substance theft in hospitals and other healthcare delivery settings

PROJECT SUMMARY Non steroidal anti inflammatory drugsNSAIDsare a first line pharmacologic pain therapy for chronic musculoskeletal painand rheumatoid arthritisRAand moderate to severe osteoarthritisOAspecificallyHoweverinsufficient pain relief by NSAID monotherapy has encouraged the use of combination therapyCombinations of NSAIDs plus weak opioids are widely used although objective evidence for e ...

PROJECT SUMMARYABSTRACTSpinal cord injurySCIaffects an estimatedAmericansDamage to nerves in the spinal cord can result in a loss of voluntary control over bladder and bowel function that often produces both incontinence and retention of urine and stools in the same patientThe standard of care for urine retention is bladder catheterization to void urinewhich may produce urinary tract infectionsUTI ...

Abstract Significance: Donor tissue shortage remains a critical problem in lung transplantation. Recent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffolds. These scaffolds, created from the donor’s tissue, become functionalized after recellularization with a patient’s own cells. However, translation of whole-lun ...