Award Data

DESCRIPTION (provided by applicant): Schizophrenia is a devastating and costly mental illness with direct and unemployment costs approaching 95 billion per year. Cognitive impairments affect the majority of patients with schizophrenia. These impairments are strongly associated with poor long-term psychosocial outcomes and reflect a large and significant unmet clinical need. FDA approval of new dr ...

This Phase 1 SBIR project aims to develop a frequency stabilized laser diode system suitable for application in optical metrology and in displacement measurement. The compact design of the semiconductor laser lends itself to many applications where a coherent light source is required, but space is at a premium. Some fields, such as precision optical metrology require a coherent light source whose ...

There is a need for a simple, portable, quantitative method to monitor the presence of Harmful Algal Blooms. Electrochemical detection offers some advantages for analysis, but traditional sensors are not practical for routine field use. Adapting colorimetric immunoassays on porous, flow-through electrodes can provide a means for rapid, low-cost, portable quantitative environmental analysis. Thi ...

Eno River Labs, LLC, (ERL) proposes to develop an onsite testing kit for dioxins that uses fluorescently tagged ssDNA aptamers for selective binding and subsequent screening and quantitative analysis of dioxin in soil sample. Current dioxin field test kits are immunoassay based, which are insufficiently specific and sometimes unreliable. Reliable dioxin testing requires laboratory ...

This research project involves the application, development, and commercial scale up of a process for the deposition of copper and copper barrier materials such as ruthenium, titanium, and other metals. This process could replace copper electroplating currently used to fill deep trenches and thin-film deposition in microelectronic circuit manufacturing. In addition, physical vapor depo ...

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DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray diffraction of these proteins is routinely performed to determine their 3D structure which needs to be ...

DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perfo ...

DESCRIPTION (provided by applicant): Rapid and accurate detection and identification of pathogens is crucial for the effective management and treatment of infectious disease. While molecular diagnostic techniques including PCR are a promising approach for rapid and sensitive detection of pathogens, they suffer from a number of technical drawbacks which have slowed their acceptance in the clinic. ...

DESCRIPTION (provided by applicant): The development of clinically effective cancer vaccines requires reliable analytical methods to evaluate the immune response to vaccination. Immunoassays are among the most sensitive and specific analytical methods that have been used widely in cancer vaccine research, most commonly to monitor the release of cytokines from T-cells in response to vaccination. A ...