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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Addressing bone marrow lesions that compromise osteochondral tissue repair

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    ABSTRACT Degenerative joint diseases such as osteoarthritis (OA) remain the source of significant pain and disability, affecting over 30 million adults with an annual US economic burden of more than $486 billion. Joint replacement is a well-established procedure, but its finite life span makes this treatment unacceptable for younger (under 65) or more active individuals. For this growing patient p ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A metabolomics-based laboratory developed test to improve the diagnostic precision of Polycystic Ovary Syndrome

    SBC: METABOLON, INC.            Topic: NICHD

    Abstract Polycystic ovary syndrome (PCOS) is a complex, multifactorial endocrine disorder characterized by hyperandrogenism, chronic anovulation, and polycystic ovaries. It is currently diagnosed by the Rotterdam criteria, which categorizes the presentation of these basic symptomologies into four main phenotypes labeled A, B, C, and D. While these phenotypes can define disease and inform clinical ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Micro-Organospheres Drug Screen to Lead Care (MODEL): a Precision Oncology Platform to Guide Breast Cancer Therapy

    SBC: XILIS INC            Topic: 102

    PROJECT SUMMARY/ABSTRACT The goal of precision oncology is to match cancer patients with medicines based on the specific biology of their tumor. Crucially, the current precision oncology paradigm – which is largely based on tumor genomic profiling – doesn’t work for the majority of patients. Since every patient’s tumor is uniquely complex, a potential solution to this “precision” probl ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Multiomic genomic mapping with long read sequencing

    SBC: Epicypher, Inc.            Topic: 400

    PROJECT SUMMARYGenomic mapping of histone post-translational modifications (PTMs), chromatin-associated proteins (CAPs), and DNA methylation (DNAme) is a powerful approach for biomedical research and drug development. Current genomics assays (e.g. ChIP-seq, CUTandRUN) rely on second generation short-read sequencing (SRS), wherein short reads (lt500bp) limit the ability to a) analyze concordance of ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Improving parent-adolescent communication about sexual and reproductive health

    SBC: Teen Health Research, Inc.            Topic: NICHD

    PROJECT SUMMARY Early adolescence, between the ages of 10-13, is a critical time for sexuality development. It is a period when most young people enter puberty and have new questions about bodies, relationships, and sexual activity. However, the majority of US adolescents enter this early adolescent period without access to the kind of inclusive, comprehensive sex education that could help them de ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Development of heparan sulfate-based therapeutics to treat inflammatory diseases

    SBC: GLYCAN THERAPEUTICS CORPORATION            Topic: 300

    Abstract More than 60 million Americans consume acetaminophen (APAP) on a weekly basis. Unfortunately, an overdose of APAP causes liver toxicity and is responsible for over half of acute liver failure cases in the US. N-acetyl cysteine is the only antidote for APAP overdose and is effective if given within 10 hours after APAP ingestion. However, many patients don’t seek out treatment during the ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Modulation of cancer induced immune suppression via inhibition of SCD1

    SBC: MODULATION THERAPEUTICS, INC.            Topic: NCI

    PROJECT SUMMARY Metabolic reprogramming plays a critical role in carcinogenesis, in part due its ability to promote immunesuppressive properties within tumors. It remains unclear whether inhibition of fatty acid metabolism in tumorsaffects their immunogenicity. We show that inhibition of stearoyl CoA desaturase 1 (SCD1), the rate limitingenzyme involved in fatty-acid synthesis converting saturated ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. CN-105 Improves Functional Outcome After Intracranial Hemorrhage

    SBC: AegisCN LLC            Topic: 106

    Annually, approximately 100,000 patients in the USA suffer from intracerebral hemorrhage (ICH), which is associated with high mortality rates and poor long-term cognitive and physical recovery. At present, no pharmacological therapies have been demonstrated to improve functional outcomes after ICH. However, we have successfully demonstrated that CN-105, a pentapeptide derived from the receptor bin ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Mucoadhesive film for the treatment of vestibulodynia

    SBC: Anelleo, Inc.            Topic: NICHD

    Abstract Vestibulodynia (VBD) is a chronic pain condition that occurs when pressure is applied to the vestibule, the area around the opening of the vagina. The condition is characterized by burning, stinging, and stabbing sensations upon touch, as well as tenderness, redness, and dryness of the vestibule. Activities known to commonly cause pain include physical touch, tampon use, intercourse, and ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. THERAPY FOR ALCOHOL USE DISORDER

    SBC: ARTIAM BIO INC.            Topic: 150

    Abstract Alcohol use disorder (AUD) is a major global health issue. In the US, AUD affects over 14 million people over the age of 18. While there are three approved drugs for AUD, less than 4% of patients eligible for pharmacotherapy are prescribed a medication – likely due to limited efficacy of currently approved agents. Also, the relapse rate for AUD continues to be exceedingly high. Thus, ne ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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