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THE OBJECTIVE OF THIS PROGRAM IS TO ESTABLISH A METHOD BY WHICH CANCER TREATMENTS NOT BEING INVESTIGATED THROUGH CONVENTIONAL CHANNELS CAN BE IDENTIFIED, ORGANIZED INTO A DATABASE, AND DISSEMINATED TO INTERESTED PARTIES. ORGANIZING THIS INFORMATION WILL PROVIDE A MEANS FOR IDENTIFYING UNSCRUPULOUS METHODS AND ALLOW THOSE TREATMENTS WITH PROMISE TO BE BROUGHT TO CLINICAL TRIALS. AN IMMEDIATE GOAL O ...

CURRENT SCIENTIFIC BIBLIOGRAPHIC DATABASES (E.G., MEDLINE) NOW PLAY A CENTRAL ROLE IN LITERATURE ACTIVITIES. THEY ARE IMPORTANT AND THEY ARE WIDELY USED. HOWEVER, THE INFORMATION EXPRESSED IN THE TITLE, ABSTRACT, AND MESH INDEXFIELDS IN THESE DATABASES IS QUITE CHAOTIC AND SKETCHY COMPARED WITH THE STRUCTURE OF MANY OTHER KINDS OF DATABASES. BECAUSE OF THESE DEFICIENCIES, COMPUTERIZED LITERATURE S ...

THE SPECIFIC AIMS OF THIS PROJECT ARE TO DETERMINE THE FEASIBILITY OF CREATING AN INTEGRATED KNOWLEDGE SYSTEM THAT PRACTICING PHYSICIANS CAN EASILY AND RAPIDLY ACCESS FOR INFORMATION FROM THE MEDICAL LITERATURE NEEDED TO SUPPORT THEIR DIAGNOSTIC AND THERAPEUTIC DECISIONS, AND TO ASSESS THE UTILITY TO PHYSICIANS OF SUCH A SYSTEM. THE KNOWLEDGE BASE WILL BE A COMBINATION OF CORE KNOWLEDGE, DERIVED F ...

LONG-TERM OBJECTIVES INCLUDE: (1) DEVELOPMENT OF AN INEXPENSIVE, MAGNETIC RESONANCE IMAGING (MRI) TISSUE-EQUIVALENT MATERIAL; (2) CONSTRUCTION OF MRI QUALITY ASSURANCE STANDARDS; AND (3) DEVELOPMENT OF COMPLEX TISSUE-EQUIVALENT ANTHROPOMORPHIC MRI PHANTOMS TO AID IN DETECTION OF PATHOLOGICAL CONDITIONS. THE FIRST TWO GOALS WILL BENEFIT THE HEALTH CARE INDUSTRY THROUGH THE DEVELOPMENT OF INNOVATIVE ...

THE SPECIFIC AIM OF THIS PROPOSAL IS TO DEVELOP A FAMILY OF SURFACE COILS FOR MAGNETIC RESONANCE IMAGING (MRI). WHEN SURFACE COILS ARE UTILIZED, MRI IMAGES SHOW IMPROVED SPATIAL RESOLUTION AND SIGNAL-TO-NOISE RATIOS. HIGH-RESOLUTION IMAGING OF THE CENTRAL NERVOUS SYSTEM, EXTREMITIES, AND PERHAPS THE CORONARY ARTERIES WILL BE POSSIBLE WITH IMPROVED SURFACE COIL DESIGN. THIS WOULD LEADTO IMPROVED DI ...

THE GOAL OF THIS PROJECT IS TO IMPROVE THE EXISTING PURIFICATION PROCEDURE, DEVELOPED BY PIEDMONT RESEARCH COMPANY, FOR THE 250 KD MELANOMA TUMOR-ASSOCIATED ANTIGEN (TAA) TO ALLOW PRODUCTION OF ADEQUATE QUANTITIES OF PURIFIEDTAA FOR CLINICAL EVALUATION. PURIFIED TAA MAY PROVE AN EFFICIENT AGENT FOR IMMUNOTHERAPY AND FOR SPECIFIC IN VITRO ACTIVATION OF PATIENT T CELLS FOR SUBSEQUENT THERAPY. BOTH T ...

MEDICAL RESEARCH FREQUENTLY INVOLVES LONGITUDINAL AND/OR MULTIVARIATE MEASUREMENTS; WHEN THE RESEARCH INVOLVES HUMANSOR LABORATORY ANIMALS, THE DATA ARE OFTEN INCOMPLETE OR INVOLVE TIME-DEPENDENT COVARIATES, PROBLEMS THAT TRADITIONALSTATISTICAL TECHNIQUES AND SOFTWARE CANNOT HANDLE PROPERLY. MANY IMPORTANT ADVANCES HAVE BEEN MADE IN STATISTICAL METHODS FOR INCOMPLETE LONGITUDINAL/MULTIVARIATEDATA ...

THE LONG-TERM GOALS OF THIS RESEARCH ARE TO CONTRIBUTE TO ANUNDERSTANDING OF THE ROLE OF PROTEIN KINASE C IN NEOPLASTIC TRANSFORMATION AND CELLULAR REGULATION BY SIGNAL TRANSDUCTION PROCESSES. PROTEIN KINASE C FUNCTIONS TO TRANSDUCE SN-1,2-DIACYLGLYCEROL SECOND MESSENGERS, PRODUCED IN RESPONSE TO GROWTH FACTORS, NEUROTRANSMITTERS, HORMONES, AND SOME ONCOGENE PRODUCTS, AND IT IS THE RECEPTOR OF TUM ...