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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A novel protein engineering tool for rapid manufacturing of designer nucleosomes

    SBC: Epicypher, Inc.            Topic: 103

    PROJECT SUMMARY Nucleosomes are the basic building blocks of chromatin and composed of bp DNA wrapped around a core histone octamer Chromatin function is controlled by the dynamic addition removal of histone post translational modifications PTMs Significantly alterations in specific PTMs are associated with changes in gene expression driving the emergence progression of many cancer ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Identification of an optimized NK2R agonist for 'on-demand' voiding

    SBC: Dignify Therapeutics LLC            Topic: NIA

    ABSTRACT In the US and other developed countries increased life expectancy has led to increases in aging related bladder dysfunction and associated lower urinary tract symptoms Aging and diabetes as well as many neurological conditions can result in underactive bladder UAB which can cause inefficient voiding discomfort and psychological distress as well as serious complications such as u ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Accelerated discovery of methylation targeted therapeutic development

    SBC: Epicypher, Inc.            Topic: 102

    Project Summary Nucleosomes are the fundamental and repeating units of chromatin consisting of DNA wrapped around a histone octamer Alterations in chromatin structure and function dramatically impact downstream gene expression and cellular physiology This epigenetic regulation is controlled by two major modifications histone post translational modifications PTMs such as histone methylation ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Peptide-based slides for improving the diagnostic quality of sputum specimens

    SBC: AFFINERGY, LLC            Topic: 102

    SUMMARY ABSTRACT Lung cancer is the leading cause of cancer related mortality in both men and women in United States with a dismal year survival rate of While surgery is the only curative option of the patients are diagnosed with inoperable advanced disease thus highlighting a lack of effective early screening methods Typically low dose computed tomography LDCT is used as the prim ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Clinical evaluation of the novel, uni-directional, Pd-103 CivaSheet for Pancreatic Cancers

    SBC: CIVATECH ONCOLOGY INC            Topic: 102

    CivaTech Oncology s mission is to provide improved radiation therapy directly to localized tumors The Company has developed a novel polymer encapsulated membrane like radiation source that emits radiation on only one side of the device the CivaSheet This directional source is compatible with open and minimally invasive surgical techniques and has FDA clearance to be used as primary or combin ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. A noninvasive method for tissue stiffness quantification in small animals with shear wave elastography

    SBC: Sonovol, Inc.            Topic: NIDDK

    Abstract Liver fibrosis a hallmark of many liver diseases affects millions of people in America every year and annually kills tens of thousands of these patients Despite very active research efforts there still have been no specific antifibrotic drugs approved by the FDA The liver disease and drug development communities do not currently have well validated low cost easy to use noninvasiv ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Web-based High School Media Literacy for Healthy Relationships

    SBC: Innovation Research And Training, Inc.            Topic: NICHD

    Project Abstract The rates of HIV AIDS other STIs unplanned pregnancies and dating violence among adolescents indicate the need for evidence based medically accurate comprehensive sexual health education However both teachers and parents face challenges in effectively teaching about sexual health and relationships leading to students receiving incomplete or inaccurate information Young peo ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Novel technologies for the detection of podocytes from preeclamptic patients

    SBC: AFFINERGY, LLC            Topic: NICHD

    SUMMARY ABSTRACT Preeclampsia is a complication of pregnancy characterized by elevated blood pressure proteinuria and endothelial dysfunction involving multiple organ systems Worldwide preeclampsia is the largest cause of fetal and maternal morbidity and mortality and accounts for nearly of maternal deaths in the United States alone each year Currently there is no approved diagnostic te ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. A novel class of anti-acne therapeutics

    SBC: Zen-Bio, Inc.            Topic: NIAMS

    DESCRIPTION provided by applicant Acne Vulgaris is a common skin disorder that affects of the population typically teenagers and young adults Over million people in the US are affected by acne generating a $ billion market for acne treatments of which is derived from prescription medications Although acne is not a life threatening condition it still has a hih psychosocial impac ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. A Bullet Proof vascular graft to prevent dialysis access cannulation injury

    SBC: Innavasc Medical, Inc.            Topic: 400

    Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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