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A NEW TECHNIQUE HAS BEEN DEVELOPED TO ASSAY CLOTTING FACTORS: SOLID-PHASE FIBRINOGEN AND LABELLED FIBRINOGEN TOGETHER ARE USED AS A SUBSTRATE TO DETECT THROMBIN GENERA- TED FROM THE CLOTTING CASCADE. WHEN THROMBIN CLEAVES BOTH FORMS OF FIBRINOGEN TO FIBRIN, THE LABELLED FIBRIN IN SOLU- TION ASSOCIATES WITH THE SOLID PHASE. THIS TECHNIQUE, WHICHHAS BEEN NAMED "ENZYME-LINKED COAGULATION ASSAY" OR EL ...

A NOVEL HORIZONTAL LIGHT PATHVISION ENHANCING SYSTEM (HLP-VES) CAPABLE OF 2X TO 6X MAGNIFICATION AND MOUNTED ACROSS THE FACIAL PLANE WILL BE STUDIED 1. SURVEY OF CURRENT USAGE OF TELESCOPIC VISION AIDS; 2. OPTIMIZATION OF OPTICAL DESIGN IN DESIRABLE MAGNIFICATION POWERS INCORPORATING THE HLP-VES PRINCIPLE; 3. PRELIMINARY DESIGNS OF OPTICAL CHASSIS AND MOUNTING; 4. IDENTIFICATION OF COMPONENT SOURC ...

THE LONG-TERM RESEARCH OBJECTIVE IS TO MAKE COMMERCIALLY AVAILABLE A MICROCOMPUTER-BASED SYSTEM TO FACILITATE PATIENT SELF-CONTROL OF INSULIN DEPENDENT DIABETES MELLITUS. THIS COMPREHENSIVE ""DIABETES IN SELF-CONTROL (DISC) SYSTEM'' IS COMPOSED OF: 1.AN INSTRUCTIONAL AND REINFORCEMENT COMPONENT FOR COMPUTER ASSISTED HOME BLOOD GLUCOSE MONITORING; 2.A COMPONENT WHICH PROVIDES COMPUTER ASSISTED INST ...

THE GOAL OF THIS PROJECT IS TO IMPROVE THE EXISTING PURIFICATION PROCEDURE, DEVELOPED BY PIEDMONT RESEARCH COMPANY, FOR THE 250 KD MELANOMA TUMOR-ASSOCIATED ANTIGEN (TAA) TO ALLOW PRODUCTION OF ADEQUATE QUANTITIES OF PURIFIEDTAA FOR CLINICAL EVALUATION. PURIFIED TAA MAY PROVE AN EFFICIENT AGENT FOR IMMUNOTHERAPY AND FOR SPECIFIC IN VITRO ACTIVATION OF PATIENT T CELLS FOR SUBSEQUENT THERAPY. BOTH T ...

MEDICAL RESEARCH FREQUENTLY INVOLVES LONGITUDINAL AND/OR MULTIVARIATE MEASUREMENTS; WHEN THE RESEARCH INVOLVES HUMANSOR LABORATORY ANIMALS, THE DATA ARE OFTEN INCOMPLETE OR INVOLVE TIME-DEPENDENT COVARIATES, PROBLEMS THAT TRADITIONALSTATISTICAL TECHNIQUES AND SOFTWARE CANNOT HANDLE PROPERLY. MANY IMPORTANT ADVANCES HAVE BEEN MADE IN STATISTICAL METHODS FOR INCOMPLETE LONGITUDINAL/MULTIVARIATEDATA ...

THE LONG-TERM GOALS OF THIS RESEARCH ARE TO CONTRIBUTE TO ANUNDERSTANDING OF THE ROLE OF PROTEIN KINASE C IN NEOPLASTIC TRANSFORMATION AND CELLULAR REGULATION BY SIGNAL TRANSDUCTION PROCESSES. PROTEIN KINASE C FUNCTIONS TO TRANSDUCE SN-1,2-DIACYLGLYCEROL SECOND MESSENGERS, PRODUCED IN RESPONSE TO GROWTH FACTORS, NEUROTRANSMITTERS, HORMONES, AND SOME ONCOGENE PRODUCTS, AND IT IS THE RECEPTOR OF TUM ...

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DESCRIPTION (provided by applicant): Rapid and accurate detection and identification of pathogens is crucial for the effective management and treatment of infectious disease. While molecular diagnostic techniques including PCR are a promising approach for rapid and sensitive detection of pathogens, they suffer from a number of technical drawbacks which have slowed their acceptance in the clinic. ...