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The emerging class of epsilon-near-zero materials (ENZ) is a promising candidate for use in non-linear optical applications including optical limiting. The Army is soliciting proof-of-concept efforts to investigate whether limiting devices can be fabricated based on this novel class of materials. Third Floor Materials, Inc. proposes a feasibility study of such a limiting device, based on its exper ...

Project Summary Computational toxicology aims to use rules, models and algorithms based on prior data for specific endpoints, to enable the prediction of whether a new molecule will possess similar liabilities or not. Our recent efforts have used sources like PubChem and ChEMBL to build predictive models for different toxicity-related and drug discovery endpoints. Our Phase I SBIR proposal called ...

PROJECT SUMMARY – Pulvinar Neuro LLC, FROHLICH Transcranial current stimulation is a form of non-invasive brain stimulation that has recently become a key tool in human neuroscience research and has emerged as a potential treatment strategy for psychiatric disorders such as depression and schizophrenia. Yet, many questions about TCS remain unanswered and its clinical potential has not yet been d ...

Project Summary The objective of ‘MegaPredict’ is to enable scientists to generate predictions for a natural product (or any molecule) and identify targets for efficacy assessment as well as identify any potential liabilities. We are building on our previous work which has compiled a comprehensive collection of datasets for structure-activity data for a broad variety of disease targets and oth ...

Abstract Emerging data indicate that those with pre-existing health conditions, such as obesity, diabetes, and heart disease, are at significantly increased risk of contracting COVID-19, as are low income and persons of color. Research also suggests that food insecurity (lack of access to affordable, nutritionally valuable food) and poor dietary intake are likely contributors to health disparities ...

Executive SummaryAccording to the American Heart Association (AHA), roughly 46% of the U.S. adult population suffers from high blood pressure (hypertension). Hypertension is one of the largest modifiable risk factors for heart disease, stroke, and renal failure and costs the U.S. healthcare system an estimated $131B annually. Prevalence continues to rise, and a 50% drop-off in medication adherence ...

PROJECT SUMMARYAlterations in chromatin regulators that target histone post translational modificationsPTMsare associated with diverse human pathologiesmost notably cancerThe ability to quantitatively assess diseaseassociated histone PTMs and their response to therapeutic intervention could have broad clinical applicationsincluding drug discoveryclinical trial designand personalized treatment regi ...

AbstractBiosynthetic or synthetic degradable hernia mesh is the fastest growing segment of the hernia mesh marketreaching$M in sales inwith Bard controllingof the US marketfollowed by GoreNovus Scientificand EthiconWhile biosynthetic mesh may be used in any type of hernia repairit is most commonly used in ventral hernia repair cases where there is an increased risk of bacterial infectionThe reason ...

PROJECT SUMMARYThe complex organization of chromatinDNA with its associated nuclear proteinsis closely tied to the regulation of gene expressionand evidence points to a central role for chromatin deregulation in tumor developmentA common analysis of chromatin regulatory protein localization is the chromatin immunoprecipitationChIPassaywhich involves crosslinking of proteins to DNAfollowed by chrom ...

Abstract The goal of the proposed research is to translate empirical evidence into a behavioral intervention targeting AthletesParentsand CoachesAPCto decrease the time between concussion injuryonset of symptomsand medical treatment among youth sport athletesNearlymillion sport related concussionsSRCare reported annually in the USand this number has been steadily increasingin part due to greater a ...