Award Data

The preponderance of biosensors under development today rely on labeling reagents such as fluorescent, radioisotopic or enzymatic tags. As a result, the added complexity of these reagents and their incorporation into the detection system has resulted in designs that are difficult to implement or that require significant sample preparation steps before introduction into the detection instrument. ...

Current geopolitical strategies require effective warfare countermeasures to protect U.S. forces against biological and chemical threats. Today's molecular biology and immunological detection technologies cannot be used to produce automated biodetectors useable in the battlefield. New, improved detection technologies are needed to minimize the impact of chemical and biological weapons on Army per ...

We will continue developing a plasmonic metamaterial with strong absorption within a narrow band that is dynamically tunable over the 8-10 micron range. A metamaterial consisting of one or more bi-layers of thin metal and dielectric films will trap, concentrate and absorb a narrow frequency band while strongly reflecting out-of-band light. Tuning the frequency of the absorption band may be achiev ...

The purpose of this contract is to develop high affinity antibodies that are specific to Burkholderia surface expressed polysaccharides. These monoclonal antibodies (mAbs) can then be used to develop diagnostics and therapeutics for melioidosis and glanders; two infectious diseases caused by the Tier 1 biothreats Burkholderia pseudomallei and mallei, respectively. The SBIR funded work to date deve ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...