Award Data

From HIV to metastatic cancer, state-of-the-art therapeutics are static biological or pharmaceutical compounds—whose efficacy is inevitably lost once their evolving disease targets sufficiently mutate. We engineered the first adaptive therapeutics designed to co-adapt with adapting disease agents—to provide ‘resistance-proof’ disease control. Known as Therapeutic Interfering Particles (‘ ...

Development of air vehicles capable of routine operation and able to achieve hypersonic speeds is paced by the availability of a propulsion system. The vision is to combine improved off-the-shelf turbines for low-speed operation (M=0 to 2+) and dual-mode ramjet (DMSJ) engine technologies for high-speed operation (M=2+ to 5+), with both engines sharing a common air inlet and a common thrust produci ...

Unlike conventional computers, the embedded computers found in vehicles, routers and other Internet of Things devices lack the capability to have their software remotely updated. Vulnerabilities discovered in such devices remain unpatched, creating a large and growing attack surface. We propose to address this limitation in our Identification and Modification of Features in Embedded Devices (IMFED ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs while providing protection against CB ...

Recent DoD programs have furthered intelligence, surveillance and reconnaissance (ISR) objectives by advancing the state-of-the-art in sensor resource management and target tracking. The majority of this work, however, has focused upon the problem of tracking a handful of high value targets for lengthy periods. There is a need to develop systems that detect anomalous activities that have the po ...

The NASA Glenn Research Center (GRC) continues to develop on SOFC technology for the aeronautics’ industry and their approach is significantly different than the approaches being pursued by the Department of Energy’s Solid Energy Conversion Alliance companies. The NASA Bi-Electrode Supported Cell (BSC) SOFC technology has the potential to provide a significant increase in power performance per ...

Impact Technologies, in collaboration with our partners Raytheon and Georgia Tech, is developing a suite of integrated components of a self-aware processing and adaptive, intelligent control system for next generation computing systems. During the Phase I program, the team developed a flexible architecture that supported development and implementation of organic computing modules. We integrated a ...

Very large aerial video collectors (VLAVCs) are of increasing interest, including such systems as Constant Hawk, Sonoma, Angel Fire and the planned ARGUS video sensor. These systems show significant potential in their ability to provide surveillance capabilities; however, the amount of data they generate is daunting, and image compression is required to store and transmit the data. In our Phase I ...

Materials Innovation Technologies LLC is developing a method for making polymer matrix composites fiber preforms that has the potential to revolutionize the industry. The Three Dimensional Engineered Preform (3-DEP) process represents the state-of-the art in chopped fiber preform manufacture. 3-DEP produces a homogeneous fiber distribution within parts and consistent part weight and dimensions f ...