Award Data

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this proposal is to demonstrate the feasibility of building a data management system for DN ...

The synthetic opioids fentanyl and carfentanil pose an imminent national security threat, given the ease with which they can be obtained, their low lethal doses, and their potential for weaponized use. The purpose of this agreement is to adapt SensoDx’s high-performance miniaturized diagnostics platform based on a programmable bio-nano-chip, with embedded artificial intelligence, to enable U.S. ...

Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmi ...

Sigma-K Corporation proposes to develop a Hermetic Textile Closure Hardware System to be used for Chemical Biological (CB) protective clothing and Collective Protection (COLPRO) portable shelter systems. Our Hermetic Textile Closure Hardware System design will allow the user to easily don and doff one's protective apparel. The system will remain intact during combat behavior. The closure interface ...

The preponderance of biosensors under development today rely on labeling reagents such as fluorescent, radioisotopic or enzymatic tags. As a result, the added complexity of these reagents and their incorporation into the detection system has resulted in designs that are difficult to implement or that require significant sample preparation steps before introduction into the detection instrument. ...

Current geopolitical strategies require effective warfare countermeasures to protect U.S. forces against biological and chemical threats. Today's molecular biology and immunological detection technologies cannot be used to produce automated biodetectors useable in the battlefield. New, improved detection technologies are needed to minimize the impact of chemical and biological weapons on Army per ...

In the wake of the September 11th attacks and subsequent Anthrax scares, researchers worldwide are working to expand our ability to rapidly assess what poses a terrorism threat to the public. The rapid detection of specific pathogens is required for biod