Award Data

DESCRIPTION provided by applicant Aquilus Pharmaceuticals Inc proposes to preclinically develop AQU for the treatment of orofacial and general neuropathic pain via a newly discovered mechanism involving matrix metalloproteinases andamp MMP MMP AQU is a non hydroxamic acid containing MMP inhibitor that is selective for both MMP and MMP and has been shown to block mech ...

DESCRIPTION provided by applicant This proposal includes trade secrets and other proprietary or confidential information of Highland Instruments and is being provided for use by the National Institutes of Health NIH for the sole purpose of evaluating this SBIR proposal No other rights are conferred This proposal and the trade secrets and other proprietary or confidential information contain ...

DESCRIPTION provided by applicant The goal of the project is to develop a therapeutic capable of sterilizing recalcitrant chronic infections such as deep seated abscess osteomyelitis endocarditis and biofilms of indwelling devices Many of these infections are essentially untreatable and lead to substantial morbidity and mortality In many cases recalcitrance of an infection is not caused b ...

DESCRIPTION provided by applicant The overall objective of this Fast Track SBIR application is to create and deploy an innovative system that will help more elders to continue living at home while being safely cared for by Personal Care Service PCS agencies Based on the research teamandapos s prior experience developing fall sensors and other technologies to allow elders to andquot age in pl ...

DESCRIPTION provided by applicant Multi drug resistance MDR in Gram negative pathogens including the Enterobacteriaceae and Pseudomonas aeruginosa poses a significant threat to our ability to effectively treat infections caused by these organisms A major component in the development of the MDR phenotype in Gram negative bacteria is overexpression of RND type efflux pumps which actively pu ...

DESCRIPTION provided by applicant Despite recent advancements in wireless sensor technology and the rapidly growing need among clinicians and researchers for body worn measurement systems current technology retains limited functionality during demanding applications such as recording uncontrolled movement disorders sports activities or activities in the work place A design breakthrough is ...

DESCRIPTION provided by applicant Developments in next generation sequencing NGS continue to increase throughput and reduce the costs for whole genome sequencing Unfortunately DNA preparation methods lag behind in both throughput and DNA quality slowing the pace of adoption of new sequencing techniques This Phase II proposal focuses on the development of an automated commercial prototype ...

DESCRIPTION provided by applicant The overall goal of this Fast Track project is to combine innovations in superconducting magnet design and new developments in solid state MRI to create a highly compact robust mobile lightweight and affordable MRI for scanning the peripheral skeleton including the knee of the majority of the public This scanner will use a unique cryogen free bore act ...

DESCRIPTION provided by applicant andquot Development of a low cost extended range autorefractorandquot This project proposal seeks to develop technologies that will lower the cost of and increase the accessibility of refractive eye care especially in low resoure settings We propose to advance our previously developed low cost handheld device capable of automati ...

DESCRIPTION provided by applicant Tetragenetics Inc an early stage biotechnology company in Cambridge MA has developed a powerful cross cutting technology for the overexpression of eukaryotic membrane and secreted proteins using Tetrahymena thermophila an important model organism with a unique features particularly well suited to the production of these important classes of proteins The com ...