Award Data

The Foster-Miller team is developing a novel coverglass system that protects photovoltaic cells on space power systems that are exposed to high doses of ionizing radiation. The spectrum of radiation a solar cell is exposed to not only provides usable energy, over time it also reduces the efficiency of the cell by darkening the barrier coverglass, escalates the operating temperature, and deteriora ...

The "troop-target" problem of automatic detection, tracking, and prediction of the formations of dismounted ground troops concealed in foliage, using FOPEN-GMTI radars introduces challenges well beyond those encountered in more conventional group-target problems. AD HOC troop formations are considerably more amorphous and unpredictable and they must be deduced from the constituent individuals. Y ...

DESCRIPTION (provided by applicant): Following a bioterrorist attack, hundreds of thousands of potential victims may require testing and treatment. The critical need to test large numbers of people for exposure to a biothreat agent may overwhelm the capacity of the clinical and public health infrastructure. The approximately 25,000 sentinel laboratories in the Laboratory Response Network, which co ...

Osteoporosis is a major community health problem for which several effective FDA approved therapies exist, but which remains largely undiagnosed and untreated. While bone densitometry using dual-energy x-ray absorptiometry (DXA) is the current "gold standard" in osteoporosis diagnosis, controlled clinical trials have highlighted its sensitivity and specificity limitations at the individual patient ...

Sensitive site exploitation activities are focused on collecting forensic evidence left behind by persons involved in terrorist or other illegal activity, and the biological evidence recovered is often referred to as"touch DNA samples". Touch samples include fingerprints, skin cells found on clothing (e.g. a shirt collar), and oral epithelial cells found on the opening of a soda can or the rim of ...

DESCRIPTION (provided by applicant): Malarial disease represents one of the most pressing medical healthcare issues facing the world today. While limited drug treatment options exist, a vaccine solution is widely considered as one of the most effective therapeutic weapons to combat malaria. Despite years of research, though, malarial vaccine initiatives have yet to produce a viable candidate. One ...

DESCRIPTION (provided by applicant): The specific aim of the Phase I and Phase II research program will be to design and build an "open", split pair coil, high field (>1 .5T), cryogen-free MRI magnet. The key innovation that will make this goal feasible is the development of an advanced, high performance, round high temperature superconductor capable of operation at 20 Kelvin. Operating at a te ...

DESCRIPTION (provided by applicant): We propose to extend our successful development of an agile spectral light source for light microscopy, funded through the NCI-IMAT initiative, into FDA trials. The SpectraLamp(tm) device enables the automated and quantitative analysis of double-immunostained samples in brightfield (non-fluorescence-based) microscopy, with particular utility for hematopatho ...

DESCRIPTION (provided by applicant): Octagen's broad, long-term objective is to complete the clinical development and secure FDA approval of its b-domain deleted recombinant factor VIII (OBI-1), a low antigenicity version of factor VIM (fVIII). OBI-1 is designed for the treatment of patients with inhibitory, neutralizing antibodies to human fVIII. Such "inhibitor" patients include congenital hemop ...

DESCRIPTION (provided by applicant): An implantable wireless flow sensor system has been under development that would enable measurement of the flow of cerebrospinal fluid (CSF) through the ventriculoperitoneal (VP) shunt, currently used to treat hydrocephalus patients. CSF flow is a key indicator of shunt function, and there is currently no way to measure it in situ, resulting in the absence ...