Award Data

DESCRIPTIONprovided by applicantThe goal of the project is to develop a therapeutic against vancomycin resistant enterococcusVREThese infections are a serious health concern because antibiotic resistance has gotten to the point where there are few or no effective treatment options availableFor the enterococciresistance is inherently linked to toleranceth ability of the pathogen to survive in the p ...

LongShortWay Inc. and Northeastern University propose a family of feature reduction and ensemble classifier methods based on Principal Component and Dynamic Logic feature clustering algorithms. New methods combine feature clustering with non-linear feature reduction via manifold learning, and bagging, boosting, and stacking ensemble algorithms.

Sensitive site exploitation activities are focused on collecting forensic evidence left behind by persons involved in terrorist or other illegal activity, and the biological evidence recovered is often referred to as"touch DNA samples". Touch samples include fingerprints, skin cells found on clothing (e.g. a shirt collar), and oral epithelial cells found on the opening of a soda can or the rim of ...

DESCRIPTION provided by applicant Cerebral cavernous malformations CCMs also known as andapos cavernous angiomaandapos or andapos cavernomaandapos are common vascular abnormalities found in of the population exposing patients to a lifetime risk of hemorrhagic stroke seizures and other neurologic sequelae Approximately of CCM lesions present with clinically overt hemorr ...

DESCRIPTION (provided by applicant): An implantable wireless flow sensor system has been under development that would enable measurement of the flow of cerebrospinal fluid (CSF) through the ventriculoperitoneal (VP) shunt, currently used to treat hydrocephalus patients. CSF flow is a key indicator of shunt function, and there is currently no way to measure it in situ, resulting in the absence ...

DESCRIPTION (provided by applicant): Pseudomonas aeruginosa infection is the leading cause of hospital-acquired pneumonia in patients undergoing mechanical ventilation. Current antibiotic treatments exhibit failure rates as high as 18%, even when the organism is susceptible to the antibiotic being administered. The goal of this project is to address this critical medical need by identifying specif ...

DESCRIPTIONprovided by applicantThe overarching objective of this proposal is to attain data for FDAksubmission of a handheld miniaturized STAT Blood Counter usingL blood to yield a complete blood countCBCwithpart differentialThis dramatically decreased size and sample volume creates new opportunities in delivery of these hematology testsultimately leading to more streamlinedavailableand on demand ...

Development of Transcatheter Cerclage Mitral Valve Annuloplasty Cerclage

Extra anatomic bypass or vascular shunts divert blood flow In congenital heart disease these surgical procedures are critical for management Children born with one functional ventricle or cardiac pumping chamber require two to three major cardiac surgery procedures for palliation The management goal is to divert systemic venous return deoxygenated blood from the heart directly to pulmonary a ...

DESCRIPTION (provided by applicant): As of 2008 the CDC estimated that there were approximately 1.1 million persons in the U.S. infected with HIV- 1 and about 56,000 new cases are diagnosed each year. During the mid-to-late 1990s, advances in treatment slowed the progression of HIV to AIDS and related deaths. Unfortunately, the treatment often leads to the emergence of drug resistant mutants of HI ...