Award Data

Bone marrow transplant (BMT) is an extraordinarily rapidly growing field, and the number of transplants in the U. S. is expected to grow from a current rate of 15,000 per year to over 100,000 per year by 1995. This rapid expansion is due to the diversity in the types of bone marrow transplantation procedures and the number of clinical procedures that can be benefitted by a BMT. Major limiting fact ...

In vitro expansion of hematopoietic cells finds many applications in the clinic. This technique hasexpanding CD34+ cells for transplantation/re infusion, although most of the technology has consistedcultures in which there is variable CFUGM expansions and failure to maintain LTC IC (long term cultuThe Investigators have found that perfusion cultures of bone marrow mononuclear cells result in expaC ...

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As the ability to communicate with the health care system becomes more important, there isa risk that minority populations, particularly non-English speaking and undeserved persons, will fallfurther behind in the level of care they receive. We are currently developing a general healthcare planfor its member companies, expected to begin in April 1994, and to be fully insured and provided inpartners ...

THE USE OF LASERS AS A SURGICAL MODALITY HAS BEEN ESTABLISHED IN RECENT YEARS. LASERS OF VARIOUS WAVELENGTHS ARE SUITED FOR DIFFERENT SPECIFIC SURGICAL FUNCTIONS. CO2 (10.6 ) RADIATION HAS SMALL PENETRATION DEPTHS IN TISSUES. THIS LEADS TO HIGH SURFACE TEMPERATURES WHICH ARE DESIRABLE FOR TISSUE INCISION THROUGH EVAPORATION. ND:YAG LASERS (1.06 ) PROVIDE VOLUMETRIC TISSUE HEATING WHICH IS EFFECTIV ...

THE OBJECTIVE OF THIS PROPOSAL IS THE DEVELOPMENT OF A PULSED MID-IR LASER IN THE 3.5 TO 4.1 MICROMETER ATMOSPHERIC TRANSMISSION WINDOW. SUCH SPECTRAL SOURCE IS RELEVANT TO A VARIETY OF TACTICAL APPLICATIONS. THE DF CHEMICAL LASER HAS BEEN THE CHOICE, BUT SUFFERS FROM WASTE FUEL MANAGEMENT PROBLEMS. NO OTHER EFFICIENT DIRECT LASING SOURCE IS AVAILABLE. TO OBTAIN SUCH A SOURCE, WE PROPOSE THE USE O ...

THE SCATTERING OF X-RAYS CAN BE USED TO IMAGE THE DENSITY OFANATOMICAL STRUCTURES UP TO SEVERAL CENTIMETERS DEEP IN THE HUMAN BODY. THIS RESEARCH DESCRIBES A TECHNIQUE OF USING COMPTOM SCATTERED X-RAYS IN AN IPSILATERAL (BACKSCATTER) GEOMETRY TO OBTAIN THREE-DIMENSIONAL DENSITY INFORMATION FORMAXILLODENTAL IMAGING. THE TECHNIQUE IS CALLED COMPTON SCATTER TOMOGRAPHY (CST). CURRENTLY, IN THIS ANATOM ...

The use of dedicated pulsatile ventricular support devices (VAD) for circulatory support is becoming an accepted treatment modality for adult patients requiring support due to post-cardiotomy pump failure or post-AMI cariogenic shock; the VAD could also be used as a bridge to transplant. Although temporary circulatory support in pediatric patients is being performed with ECMO or centrifugal pumps, ...

A bearingless disposable centrifugal blood pump will be developed in this project, together with ainexpensive driver and controller. The rotor of the pump will be suspended by a combination of magnethat it is washed on all surfaces by moving blood. The elimination of bearings and shaft seals removheating and blood stagnation, making such a pump safer and more reliable for short to medium term usp ...

Our objective is to develop a laser welding technique for applications in urologic anastomotic repalaparoscopic procedures in which conventional suturing techniques are difficult. The project is desistrength of welds in a bladder augmentation procedure (enterocystoplasty) under feedback controlledmode to achieve desired preset surface temperature of the tissue favorable to reproducible weld intewi ...