Award Data

N/A

DESCRIPTION (provided by applicant): Phosphoinositides (PIPnS) are integral signaling molecules for cellular communication. By recruiting specific proteins to the inner membrane, signal cascades are then initiated leading to downstream effects such as protein sorting, tumorigenesis, regulation of exo-and endocytosis, control of cell shape, cell migration and proliferation, and apoptosis. Discoveri ...

DESCRIPTION (provided by applicant): The purpose of this Phase I project is to produce and pilot test the feasibility of learner-managed professional-development packages for teachers to use to learn how to create safe, supportive learning communities in their classrooms to enable students to learn the necessary social and cognitive skills to maintain ...

DESCRIPTION (provided by applicant): Cystic fibrosis is the most common autosomal recessive genetic disease in the United States. With the recent recommendation for multi-mutation CF screening by the ACMG/ACOG, more labs will be implementing multiplexed genotyping assays. Presently, DNA diagnostic tests for CF are expensive, complicated to run and limited to certain ethnic backgrounds. Using a po ...

DESCRIPTION (provided by applicant): The goal of this project, over Phase I and Phase II, is to develop and validate a new diagnostic platform for biowarfare detection that provides ultrafast design and implementation. Today, both the scientific and security communities believe that advances in biotechnology have increased the concern for misuse in biological weapon programs. As reports of anthra ...

DESCRIPTION (provided by applicant): The long-term objective of this project is to develop a new and novel medical monitoring device aimed at benefiting a large class of diabetic individuals. The new device is being called an "Assisted Self- Management Monitor." There are many diseases, such as diabetes, which are considered "self-managed" diseases. With diabetes, it is expected that patients m ...

INITIAL DESIGN AND TESTING OF THE MICROMATH SCIENTIFIC COMPUTING ENVIRONMENT (MMSCE) WILL BE CARRIED OUT. THE MMSCE EMBODIES AN OBJECT ORIENTED APPROACH TO SCIENTIFIC COMPUTING. "COMPUTATIONAL NODES" ARE DEFINED HERE AS ENTITIES BETWEEN WHICH DATA AND OTHER MESSAGES FLOW. IN THE MMSCE, THE SCENTIST-USER MANIPULATES COMPUTATIONAL NODES, AUTOMCATICALLY LINKING POTENTIALLY DIVERSE TYPES OF SCIENTIFIC ...

DESCRIPTION (provided by applicant): The tremendous progress made in the medical sciences and genomics has given rise to a plethora of new candidate drug targets. However, it is becoming increasingly apparent that a major bottleneck in the drug discovery process is not always drug design per se, but rather identification of which of the candidate targets most contributes to the particular diseased ...

DESCRIPTION (provided by applicant): A critical failure of conventional clinical trial technology is that it does not adequately address strict new regulatory requirements, the increasingly distributed and community based nature of clinical trials and their increasing number, cost and complexity. An innovative, secure, Internet based technology is proposed that does. Strong preliminary results sup ...

DESCRIPTION (provided by applicant): Sleep-related automobile accidents account for 1,500 deaths and 71,000 injuries annually, and sleep-related problems are known to affect both the productivity and safety of the American workplace. The National Sleep Foundation estimates the annual cost to be $100 billion. In Phase I, a low-cost, low-stress, tethered electroencephalographic (EEG) and electromyog ...