Award Data

DESCRIPTION provided by applicant The laboratory rat is a preferred rodent model in pre clinical drug studies Their larger size facilitates procedures otherwise difficult in mice includng studies using instrumentation blood sampling and surgeries and allows for ten times the amount of tissue collection Although rats are often more suitable than mice for pharmacological toxicological phy ...

DESCRIPTION provided by applicant In the absence of effective approved drugs or vaccines vector control remains the only means of intervention for many against mosquito borne diseases This problem grows more complex with the recent establishment of multiple exotic mosquito species and mosquito borne pathogens Furthermore changing climate conditions are predicted to alter the traditional ra ...

DESCRIPTION provided by applicant Neurodegenerative and malignant diseases of the central nervous system affect millions of Americans These diseases are often devastating and difficult to treat and effective drug delivery remains a significant challenge Infusion of drugs nto the brain parenchyma using convection enhanced delivery CED allows direct treatment of lesions circumventing the bl ...

DESCRIPTION provided by applicant The purpose of this Phase II Small Business Technology Transfer STTR project is to complete development and evaluate usability and effectiveness of the Wraparound Team Monitoring System Wrap TMS a web based electronic behavioral health information system EBHIS for the most widely implemented care coordination model in childrenandapos s behavioral healt ...

DESCRIPTION provided by applicant VisionQuest Biomedical and its collaborators have assembled a team of inter disciplinary scientists with considerable experience in automated retinal image analysis clinical ophthalmology with specialized research in malarial retinopathy MR and cerebral malaria diagnosis CM This team will develop and test an automated MR screening software system integra ...

DESCRIPTION provided by applicant Genital tract infection with Neisseria gonorrhoeae gonorrhea does not induce a state of specific protective immunity and can be acquired repeatedly Despite public health measures the disease persists at an unacceptably high frequency there is no vaccine against it and resistance even to the latest generations of antibiotics continues to emerge Recent fin ...

DESCRIPTION provided by applicant This project aims to generate blood tests for mild cognitive impairment MCI and conversion risk from MCI to full blown Alzheimerandapos s disease AD We have reported that systemic footprints increases in key micro RNA miR levels are identifiable in AD blood samples here we suggest that this is also true for MCI the pre AD phase Our recent ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is in removing sulfur compounds from various fuels such as diesel, gasoline and mixture of refined fuels known as transmix. It is critically important to reduce sulfur levels below 10 ppm as the emissions from transportation vehicles can cause acid rain and associated undesired effects. Sulfu ...

The need for the United States Navy to maintain a superior global Anti-Submarine Warfare capability is heavily dependent on sonobouys and Navy has identified a need to develop batteries to power sonobuoys which have higher power capabilities than currently used technology. Nanowise LLC proposes to develop a high power MnO2/CFx battery based on interpenetrating conductive network of nanostructures. ...

The need for human trainers to role-play the participants with whom a trainee must interact limits the effectiveness of both simulators and part task training (PTT) devices for individuals and small groups. The objective of this research is to design and prove the feasibility of our architecture for speech-enabled, synthetic role-players for a generalized PTT device or simulator for P-8A Tactical ...