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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Islet culture, shipping, and infusion device

    SBC: WILSON WOLF MANUFACTURING CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The culture and shipment of islets are an integral part of islet transplant research. Flasks, petri dishes, and bags are the devices used to perform that role. However, these devices have inherent design characteristics that make them poorly suited to the unique needs of islet culture and islet shipping. This results in the use of far too many devices to maint ...

    SBIR Phase II 2008 Department of Health and Human Services
  2. Arterial-Mimetic Grafts Molded from Purified Proteins

    SBC: Gel-Del Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Peripheral artery disease and trauma are leading causes of morbidity and amputation in the United States. Recent advances in biomaterials provide for potential development of small diameter vascular grafts as a life-saving treatment. Development of a life-long graft (lt 6 mm id) requires a construct that will not cause significant blood clotting/thrombosis and ...

    SBIR Phase II 2009 Department of Health and Human Services
  3. Photodynamic Treatment of Endotracheal Tube Biofilms

    SBC: Advanced Photodynamic Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Ventilator-associated pneumonia (VAP) is a common, significant, life threatening and unaddressed infectious disease problem that occurs in patients who are intubated with an endotracheal tube and require mechanical ventilation. Of the l .6 million patients per year in the US who require mechanical ventilation, 15-25% will develop VAP and 24-71% will die of th ...

    SBIR Phase II 2005 Department of Health and Human Services
  4. Treatment of Cerebral Edema Using Ventricular Therapy

    SBC: TWIN STAR MEDICAL            Topic: NINDS

    DESCRIPTION (provided by applicant): Cerebral edema is arguably the most serious complication of severe traumatic brain injury (TBI). The central HYPOTHESIS is that increasing osmolality of cerebrospinal fluid (CSF) will move free water out of tissue into the ventricles where it can be removed, thereby reducing cellular swelling, intracranial pressure (ICP), and cell death; ultimately improvin ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Anticoagulum Cardiac RF Ablation Catheter (Direct Phase II)

    SBC: FOCUSSTART, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Radio Frequency RF catheter ablation for atrial fibrillation AF may prevent stroke but paradoxically the procedure itself can cause stroke or other ischemic cerebrovascular events Cognitive dysfunction may arise in to of cases after cardiac ablation procedures and MRI studies have identified between and incidences of andquot silentandquot ...

    SBIR Phase II 2015 Department of Health and Human Services
  6. A Device to Quantify Sweat of Single Sweat Glands to Diagnose Neuropathy

    SBC: Neuro Devices, Inc.            Topic: 107

    DESCRIPTION provided by applicant We devised a new generation highly sensitivity method to diagnosis peripheral neuropathy early when the probability for reversal is greatest Cancer chemotherapy and diabetes are the most common causes of neuropathy in the USA Both cause decreased sweating abnormal circulation peripheral numbness pain and weakness If diagnosed early both are potentially ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  7. Treatment of Cerebral Edema using Ventricular Therapy

    SBC: TWIN STAR MEDICAL            Topic: N/A

    DESCRIPTION (provided by applicant): Cerebral edema is associated with traumatic brain injury. The overall HYPOTHESIS of the proposed intervention is that free water removed from the brain following traumatic injury will minimize cerebral edema. Approach: The applicant proposes to complete preclinical development of an innovative catheter for the reduction of cerebral edema. The initial clinical ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Arterial-Mimetic Grafts Molded from Purified Proteins

    SBC: Gel-Del Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Atherosclerotic vascular disease, in the form of coronary artery and peripheral vascular disease, is the leading cause of mortality in the United States. Despite vast improvements in the field of biomaterials, a useful biocompatible material is still not available for the production of small vascular grafts largely because of blood clotting/thrombosis. To overc ...

    SBIR Phase II 2006 Department of Health and Human Services
  9. Tools for Distance Delivery of an Evidence-based AD Family Caregiver Intervention

    SBC: HEALTHCARE INTERACTIVE, INC.            Topic: NIA

    DESCRIPTION provided by applicant As the US population ages Alzheimerandapos s disease and related disorders ADRD will present an emotional and financial burden to an increasing number of families and the U S healthcare system More than of the care for persons with ADRD is provided by family members at home who need ongoing support to manage the daunting physical and psychological demands of care ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a novel drug treatment for decompensated heart failure.

    SBC: Madeleine Pharmaceuticals Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The Specific Aim of this direct to Phase II proposal is to carry out IND enabling work for our drug Vastiras r Our first therapeutic target patient population is the people who suffer from acute decompensated heart failure ADCHF or AHF and present with renal compromise These patients are hospitalized when diagnosed and become stable for a while ...

    SBIR Phase II 2016 Department of Health and Human Services

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