Award Data

DESCRIPTION (provided by applicant): The Health and Retirement Study is one of the world's most important data resources for the study of aging. The basic longitudinal survey instrument has been supplemented with data from a variety of other sources including Social Security Administration records containing the detailed earnings history of the respondent. Under current HRS protocols, the use of t ...

AEgis Technologies Group Inc. proposes to develop a multichannel multichip module (MCM) capable of high-speed digital-to-analog data conversion and suitable for integration into the next generation of Ladar and Radar HWIL test infrastructure. AEgis will leverage existing SBIR programs by utilizing key components and integrating them in a single subsystem module. The resulting MCM will be capable ...

DESCRIPTION (provided by applicant): The role of proteoglycans and carbohydrate polymers such as heparan sulfate in biological processes are becoming better understood, but this new frontier has only begun to be explored. Tissue regeneration is also an emerging frontier. This proposed research, when completed, will make an important contribution to both the proteoglycan and tissue regenerative fie ...

DESCRIPTION (provided by applicant): The role of proteoglycans and carbohydrate polymers such as heparan sulfate in biological processes are becoming better understood, but this new frontier has only begun to be explored. Tissue regeneration is also an emerging frontier. This proposed research, when completed, will make an important contribution to both the proteoglycan and tissue regenerative fie ...

DESCRIPTION (provided by applicant): Highly-integrated and complex tissue and organ culture-based assays, such as organotypic brain slices and dissociated cortical cultures, have great potential to contribute to the understanding of basic CNS processes, disease states, pharmacological and toxicological properties of drugs. The information-dense analyses of these cultures using multiunit extra cell ...

DESCRIPTION (provided by applicant): The "Big Idea" driving this project is that human memory is small, the body of scientific knowledge is vast and that breakthroughs are possible if software can do a better job of connecting researchers with knowledge in text and databases. The first step is to stop looking for words (as a search engine does) in data but instead try to find facts in data. A fact ...

Reliable, high speed communications are critical to the successful completion of postulated missile defense engagements. Importantly, interceptor kill vehicles (KV) and carrier vehicles (CV) must meet mission performance requirements under hostile threat conditions and while exposed to direct and indirect radiation effects. The interceptor modem is a key communications link. Modem capability an ...

Reliable, capable, and radiation hardened control electronics are critical and needed for successful completion of postulated missile defense engagements. These electronics are used in motor controllers and divert and attitude control systems (DACS) for missile interceptors and space systems. The existing GBI Booster stage 2 and 3 TVCs, a.k.a. Electronics Control Unit (ECU), have not been harde ...

DESCRIPTION (provided by applicant): Acute liver failure (ALF) constitutes a challenge to clinicians and scientists alike. Commonly associated with the alcohol-acetaminophen syndrome, its clinical course is unpredictable and polarizing, with death as the outcome in a large percentage of cases. Given the lack of specific therapy, organ transplantation is the only clinically effective strategy. Cons ...

DESCRIPTION (provided by applicant): Progressive renal disease remains an unsolved challenge for the nephrologist, as it almost inevitably leads to end-stage renal failure, a life-threatening condition that necessitates renal replacement therapy. Few, if any, of the currently practiced therapeutic strategies oppose the molecular and cellular programs of apoptosis and fibrosis that drive renal dise ...