Award Data

APPLIED GENETICS LABORATORIES, INC. PROPOSES TO UTILIZE NEWLY DEVELOPED MOLECULAR GENETIC TECHNIQUES TO ANALYZE THE SPECTRUM OF MUTAGENIC EVENTS THAT OCCUR AT THE TK AND HPRT LOCI IN MOUSE L5178Y CELLS. THE PURPOSE OF THESE STUDIES ISTO DETERMINE IF THE SPECTRUM OF GENETIC ABNORMALITIES REGISTERED AT THESE LOCI IS A FUNCTION OF THE HETEROZYGOUS/HOMOZYGOUS NATURE OF THE GENE LOCI INVOLVED, AND TO C ...

CONCERN ABOUT THE EFFECTS OF HEARING IMPAIRMENT ON A CHILD'S DEVELOPMENT IS CAUSING HEARING EVALUATION TO BECOME A ROUTINE PART OF PEDIATRIC CARE. WHILE THE COMMERCIAL MARKET HAS FOCUSED ON THE IMPROVEMENT OF ELECTROPHYSIOLOGIC PROCEDURES AND EQUIPMENT, BEHAVIORAL PROCEDURES WHICH MAY BE MORE APPROPRIATELY USED WITH OLDER INFANTS AND CHILDREN HAVE BEEN LARGELY IGNORED. THE OVERALL GOAL OF THIS PRO ...

BIRCH & DAVIS ASSOCIATES, INC. WILL DETERMINE THE FEASIBILITY OF ESTABLISHING A METHADONE MAINTENANCE TREATMENT PROGRAM NETWORK FOR TRAVELING CLIENTS. ALL METHADONE PROGRAMS LOCATED WITHIN THE UNITED STATES WILL BE IDENTIFIED THROUGH CONTACT WITH FEDERAL AGENCIES (E.G., NATIONAL INSTITUTE ON DRUG ABUSE, FOOD AND DRUG ADMINISTRATION, DRUG ENFORCEMENT ADMINISTRATION), STATE AGENCIES, AND OTHER ORGAN ...

THE LONG-RANGE GOAL OF THIS PROJECT IS TO ESTABLISH A TRAINING CERTIFICATION SYSTEM WHEREBY OPERATORS AND STAFF OF BOARD AND CARE HOMES FOR DEVELOPMENTALLY DISABLED RESIDENTS THROUGHOUT THE UNITED STATES CAN RECEIVE UNIFORM, VALIDATED FIRE SAFETY TRAINING. TWO LEVELS OF TRAINING WILLBE DEVELOPED. LEVEL I CERTIFICATION FOR OPERATORS AND STAFF WILL BE DEVELOPED, TESTED, AND EVALUATED DURING PHASE I. ...

BECAUSE OF THE RAPIDLY INCREASING USE OF IN SITU DNA SEQUENCE MAPPING TO MITOTIC CHROMOSOMES, A CENTER SHOULD BE ESTABLISHED TO DEVELOP THE MOST EFFICIENT TECHNIQUES AND TO AUTOMATE THE PROCEDURE. SUCH A CENTER WOULD MAKE AVAILABLE TO LABORATORIES INVOLVED IN THE CLONING OF DNA SEQUENCES THEABILITY TO EFFICIENTLY MAP TH SEQUENCES TO MAMMALIAN CHROMOSOMES. DNA SEQUENCING BY IN SITU HYBRIDIZATION WO ...

USING ITS PROPRIETARY PROTEIN ENGINEERING TECHNOLOGY GENEX HAS DESIGNED AND PRODUCED A NOVEL ANTIGEN-BINDING PROTEIN. THE DNA SEQUENCES FOR THE HEAVY (H) AND LIGHT (L) CHAINS OF A MONOCLONAL ANTIBODY TO BOVINE GROWTH HORMONE (BGH) HAVEBEEN CLONED AT GENEX AND MODIFIED TO ENCODE THE ANTIGEN-BINDING FRAGMENT I.E., THE FV FRAGMENT, AS A SINGLE POLYPEPTIDE CHAIN OF ABOUT 240 AMINO ACIDS. TO ACHIEVE TH ...

THIS PROJECT IS INTENDED TO RESULT IN AN INFRARED FIBER LASER CATHETER FOR USE IN LASER ANGIOPLASTY, OPHTHALMIC SURGERY, NEUROSURGERY, AND ENDOSCOPIC MICROSURGERY WHERE PRECISION OF TISSUE REMOVAL IS A NECESSITY. THE FIBER WILL BE MADE FROM ZIRCONIUM FLUORIDE GLASS, WHICH HAS VERY LOW LOSS AT 2.9 MICRONS, THE WAVELENGTH OF MAXIMUM TISSUE ABSORPTION. IMPROVEMENTS WILL BE MADE IN THE FIBER STRENGTH, ...

LEARNING DISABILITIES, HYPERACTIVITY, AND OTHER DEVELOPMEN- TAL DISORDERS ARE STRESSFUL AND OFTEN PRODUCE SERIOUS EMOTIONAL DISTRESS AND BEHAVIOR PROBLEMS. LEARNING DIS- ABILITIES ALSO HAVE KNOWN NATURAL HISTORIES AND SPECIFIC REHABILITATIVE APPROACHES THAT ARE REMEDIAL AND THAT TEACH THROUGH COMPENSATORY AVENUES THAT HAVE BEEN USED FOR FIFTY YEARS, YET MANY PROBLEMS EXIST. LEARNING DISABILITY SER ...

RECENT CLINICAL INVESTIGATIONS HAVE INDICATED THAT DIETARY SUPPLEMENTS OF EICOSAPENTAENOIC ACID (EPA) CAN REDUCE SERUM TRIGLYCERIDE AND CHOLESTEROL LEVELS. FURTHERMORE, INITIAL STUDIES HAVE REPORTED A SELECTIVE KILLING OF CERTAIN HUMAN CANCER CELLS BY TREATMENT OF THIS OMEGA-3 POLYUNSATURATED FATTY ACID. IF THESE PRELIMINARY FINDINGS ARE CONFIRMED, EPA MAY SOON BY CONSIDERED A VALUABLE FOOD ADDITI ...

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