Award Data

A FEASABILITY STUDY IS BEING CONDUCTED TOWARD DEVELOPMENT OFA STAND-ALONE DATABASE PRODUCT FOR PERSONAL COMPUTERS FEATURING LINKED ACCESS TO MULTIPLE DATABASES OF INTEREST TO MOLECULAR BIOLOGISTS. ALL DATA AND ACCESS SOFTWARE WILL BE LOCATED ON A COMPACT DISK SO THAT NO CONNECTION TO EXTERNAL COMPUTER RESOURCES WILL BE REQUIRED. THE DATABASESENVISAGED INCLUDE GENBANK (TM), PROTEIN IDENTIFICATION R ...

THE APPLICATION OF PHYSICAL-CHEMICAL PRINCIPLES TO BIOLOGICAL SYSTEMS FREQUENTLY LEADS TO SITUATIONS IN WHICH THE QUANTITATIVE TREATMENT OF CONCEPTUALLY SIMPLE MODELS IS CONFOUNDED BY THE COMPLEXITY OF THE SYSTEM. SUCH IS THE CASE, FOR EXAMPLE, IN THE STUDY OF THE PERMEATION (AND POSSIBLE CONCURRENT METABOLISM) OF DRUGS THROUGH COMPLEX BIOLOGICAL MEMBRANES, THE PHYSIOLOGICAL MODELING OF THE DISTRI ...

A QUALITY CONTROL (QC) TEST KIT WILL BE DEVELOPED AND AND VALIDATED FOR USE IN MEASURING THE PERCENTAGE OF IMMUNOREACTIVE RADIOACTIVITY OF RADIOLABELED ANTIBODY OR ANTIBODY FRAGMENTS INTENDED FOR PATIENT USE. THIS QC PRODUCT IS BEING DESIGNED FOR A MULTICENTERED CLINICAL TRIALOF COMPOUNDED, RADIOLABELED ANTIBODIES. PANELS OF CURRENTLYAVAILABLE MONOCLONAL ANTIBODIES (MABS) THAT HAVE POTENTIAL FOR T ...

TECHNICAL RESEARCH ASSOCIATES, INC. PROPOSES THE DEVELOPMENTOF A NOVEL PLATELET-HARVESTING SYSTEM BASED ON A PREVIOUSLY DEVELOPED ULTRASOUND SEPARATION TECHNOLOGY. THIS TECHNOLOGY, DEVELOPED UNDER AN NHLBI GRANT, ALLOWS THE SEQUENTIAL SEPARATION OF CELLS BASED ON THEIR SIZE, EVEN THOSE CELLS THAT HAVE IDENTICAL DENSITIES. FIRST, RESIDUAL ERYTHROCYTES AND LARGE LEUKOCYTES CAN BE SEPARATED FROM PLAT ...

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PROTOTYPE SCANNING SYSTEM FROM WHICH NOVEL AND ADVANCED ULTRASOUND SCANNING SYSTEMS CAN BE MANUFACTURED FOR THE IMAGING, TISSUE CHARACTERIZATION, AND DIAGNOSIS OF CANCER AND OTHER DISEASES. IT WILL GIVE SUPERIOR IMAGES OF OBSTETRICAL CONDITIONS, VASCULAR DISEASE, LIVER DISEASE, ANDOTHER ABDOMINAL CONDITIONS. THIS ADVANCED SYSTEM IS BASED ON E ...

POLYMERIC OR CERAMIC INSULATORS CONVENTIONALLY ARE BEING USED IN HIGH VOLTAGE PULSED SYSTEMS. NEW APPROACHES ARE NEEDED THAT WOULD REDUCE INSULATORS RING THICKNESSES AND INCREASE CORRESPONDING GRADING RINGS FLASHOVER VOLTAGE. SUCH AN APPROACH WOULD POSSESS IN COMPARISON TO CONVENTIONAL INSULATORS: HIGHER SURFACE FLASHOVER FIELD STRENGTH; SMALLER PHYSICAL DIMENSIONS FOR EQUIVALENT VOLTAGE HOLDOFF; ...

THE DEVELOPMENT OF HIGH POWER, LOW IMPEDANCE, LIGHTWEIGHT ENERGY STORAGE TRANSMISSION LINES FOR PULSE-POWER APPLICATIONS IS CRUCIAL FORSMALLER, LIGHTWEIGHT, SPACE-BASED, PULSE-POWER SYSTEMS. DEVELOPMENT OF HIGH DIELECTRIC ENERGY STORAGE LINE TECHNOLOGY WOULD GREATLY REDUCETHE SIZE, WEIGHT, AND COMPLEXITY OF PULSE POWER SYSTEMS UTILIZING THESE TYPES OF COMPONENTS. EFFICIENT TRANSPORT OF 400KV, 100K ...

A NEED EXISTS TO DEVELOP A SMALLER, LIGHTER, MORE EFFICIENT, AND MORE RELIABLE CLINICAL GAS ANALYZER FOR RESPIRATORY AND ANESTHETIC GAS MONITORING. EXISTING LASER RAMAN-BASED INSTRUMENTATION USES A LARGE, HEAVY, AND EXTREMELY INEFFICIENT (0.1 PERCENT) ARGON ION LASER WITH AN INTRACAVITY GAS CELL THAT IS SUBJECT TO CONTAMINATION AND MISALIGNMENT. THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO IMPLE ...

A PROTOTYPE FOR A COMPUTER-CONTROLLED INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEM (IRASS) FOR MEDICAL LABORATORIES WILL BE DEVELOPED. THIS SYSTEM WILL INCLUDE A DATABASE IN THE CONTROLLING COMPUTER FOR TRACKING THE STORAGE AND RETRIEVAL OF SPECIMENS, A BAR CODE READER FOR VERIFICATION, AND VARIOUS ROBOTIC HARDWARE FOR THE MOVEMENT OF SPECIMENS. WHEN COMPLETED THE SYSTEM WILL AUTOMATICALLY ST ...

THERE IS A GROWING NEED TO BETTER MONITOR NEUROMUSCULAR BLOCKAGE DURING AND IMMEDIATELY AFTER ANESTHESIA. EXPERTS STATE THAT THE ONLY RELIABLE METHOD OF MONITORING NEUROMUSCULAR FUNCTION IS BY STIMULATING A PERIPHERAL NERVE AND MEASURING THE EVOKED RESPONSE OF A SKELETAL MUSCLE. NEUROMUSCULAR MONITORING HELPS THE ANESTHESIOLOGIST WITH A MORE PREDICTABLE AND RATIONAL APPROACH TO THE USE OF MUSCLE R ...