Award Data

DEVELOPMENTAL TECHNOLOGIES PROPOSES TO DEVELOP THE MAP-SCREEN, A SHORT SCREENING TEST TO DETERMINE WHICH PRESCHOOL-AGED CHILDREN ARE AT RISK FOR LEARNING DISABILITIES. THE MAP-SCREEN WILL BE DEVELOPED FROM THE RESEARCH OF THE MILLER ASSESSMENT FOR PRESCHOOLERS (MAP), A MORE COMPREHENSIVE, PREDICTIVE INSTRUMENT, AND SERVE AS A COMPANION PRODUCT TO THE MAP. THE MAP-SCREEN IS BEING PROPOSED IN DIRECT ...

THE APPLICATION OF PHYSICAL-CHEMICAL PRINCIPLES TO BIOLOGICAL SYSTEMS FREQUENTLY LEADS TO SITUATIONS IN WHICH THE QUANTITATIVE TREATMENT OF CONCEPTUALLY SIMPLE MODELS IS CONFOUNDED BY THE COMPLEXITY OF THE SYSTEM. SUCH IS THE CASE, FOR EXAMPLE, IN THE STUDY OF THE PERMEATION (AND POSSIBLE CONCURRENT METABOLISM) OF DRUGS THROUGH COMPLEX BIOLOGICAL MEMBRANES, THE PHYSIOLOGICAL MODELING OF THE DISTRI ...

A QUALITY CONTROL (QC) TEST KIT WILL BE DEVELOPED AND AND VALIDATED FOR USE IN MEASURING THE PERCENTAGE OF IMMUNOREACTIVE RADIOACTIVITY OF RADIOLABELED ANTIBODY OR ANTIBODY FRAGMENTS INTENDED FOR PATIENT USE. THIS QC PRODUCT IS BEING DESIGNED FOR A MULTICENTERED CLINICAL TRIALOF COMPOUNDED, RADIOLABELED ANTIBODIES. PANELS OF CURRENTLYAVAILABLE MONOCLONAL ANTIBODIES (MABS) THAT HAVE POTENTIAL FOR T ...

ANY VERY HIGH LEVEL LANGUAGE (VHLL) FOR STRATEGIC DEFENSE REQUIRES A COMPILER. NEW META COMPILERS USING ADVANCED ARTIFICIAL INTELLIGENCE METHODS ARE BEING STUDIED SO THAT EVENTUAL VHLL APPLICATION SOFTWARE CAN BE EFFECTIVELY PORTED TO THE SEVERAL GROUND-BASED/SATELLITE-BASED MACHINES. TO DO SO REQUIRES A META COMPILER THAT CAN COMPILE CODE TO DIVERSE ARCHITECTURES. RESEARCH WITH META COMPILERS DEM ...

SYNERGEN, INC.'S PROPOSED RESEARCH WILL DEVELOP, THROUGH RECOMBINANT DNA METHODS, NEW AGENTS TO CONTROL DENTAL PLAQUETHESE WILL CONSIST OF AN ENZYMATIC MOIETY OF THERAPEUTIC VALUE FUSED WIH AN ADHESIVE PEPTIDE THAT BINDS SPECIFICALLY AND STRONGLY TO DENTAL SURFACES. THE LATTER ARE TERMED ADHESON SEQUENCES, AND THE RESULTING TECHNOLOGY, ADHESON TECHNOLOGY. USING ADHESON TECHNOLOGY TO IMMOBILIZE ENZ ...

TECHNICAL RESEARCH ASSOCIATES, INC. PROPOSES THE DEVELOPMENTOF A NOVEL PLATELET-HARVESTING SYSTEM BASED ON A PREVIOUSLY DEVELOPED ULTRASOUND SEPARATION TECHNOLOGY. THIS TECHNOLOGY, DEVELOPED UNDER AN NHLBI GRANT, ALLOWS THE SEQUENTIAL SEPARATION OF CELLS BASED ON THEIR SIZE, EVEN THOSE CELLS THAT HAVE IDENTICAL DENSITIES. FIRST, RESIDUAL ERYTHROCYTES AND LARGE LEUKOCYTES CAN BE SEPARATED FROM PLAT ...

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PROTOTYPE SCANNING SYSTEM FROM WHICH NOVEL AND ADVANCED ULTRASOUND SCANNING SYSTEMS CAN BE MANUFACTURED FOR THE IMAGING, TISSUE CHARACTERIZATION, AND DIAGNOSIS OF CANCER AND OTHER DISEASES. IT WILL GIVE SUPERIOR IMAGES OF OBSTETRICAL CONDITIONS, VASCULAR DISEASE, LIVER DISEASE, ANDOTHER ABDOMINAL CONDITIONS. THIS ADVANCED SYSTEM IS BASED ON E ...

POLYMERIC OR CERAMIC INSULATORS CONVENTIONALLY ARE BEING USED IN HIGH VOLTAGE PULSED SYSTEMS. NEW APPROACHES ARE NEEDED THAT WOULD REDUCE INSULATORS RING THICKNESSES AND INCREASE CORRESPONDING GRADING RINGS FLASHOVER VOLTAGE. SUCH AN APPROACH WOULD POSSESS IN COMPARISON TO CONVENTIONAL INSULATORS: HIGHER SURFACE FLASHOVER FIELD STRENGTH; SMALLER PHYSICAL DIMENSIONS FOR EQUIVALENT VOLTAGE HOLDOFF; ...

THE DEVELOPMENT OF HIGH POWER, LOW IMPEDANCE, LIGHTWEIGHT ENERGY STORAGE TRANSMISSION LINES FOR PULSE-POWER APPLICATIONS IS CRUCIAL FORSMALLER, LIGHTWEIGHT, SPACE-BASED, PULSE-POWER SYSTEMS. DEVELOPMENT OF HIGH DIELECTRIC ENERGY STORAGE LINE TECHNOLOGY WOULD GREATLY REDUCETHE SIZE, WEIGHT, AND COMPLEXITY OF PULSE POWER SYSTEMS UTILIZING THESE TYPES OF COMPONENTS. EFFICIENT TRANSPORT OF 400KV, 100K ...

THE GOAL OF THIS PROJECT IS THE DEVELOPMENT OF AN ACOUSTO- ELECTRIC SOLID STATE DETECTOR SENSITIVE TO ULTRASONIC POWER.THIS RESEARCH ANSWERS THE NEED FOR IMPROVEMENTS IN ULTRA- SOUND DOSIMETRY FOR MONITORING THE OUTPUT OF DIAGNOSTIC IMAGING SYSTEMS AND FOR SUPPORTING RESEARCH IN NEW AREAS SUCH AS ULTRASOUND INDUCED HYPERTHERMIA. THIS PROJECT WOULDFOCUS ON THE DEVELOPMENT OF AN ACOUSTOELECTRIC DETE ...