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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. High throughput multiplexed characterization and modeling of antibody antigen binding with application to HSV

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials

    SBC: ApolloDx , LLC            Topic: NIDA

    Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials Thirty to over eighty percent of patients enrolled in pharmaceutical clinical trials do not comply with trial protocols by discarding the drug under investigation or not using the proper dosages This common practice compromises the medica ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Tessa Sleep Quality Monitoring

    SBC: EPITEL, INC.            Topic: NHLBI

    ABSTRACT TessaTM is validated medical device wearable capable of providing clinical sleep quality metrics for multiple nights to assess the efficacy of a sleep disorder treatment Tessa records the forehead EEG to stage sleep in an automated report that tracks changes in sleep architecture before and after a treatment for many sleep disorders such as obstructive sleep apnea and insomnia There is ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Stream Dx: accurate and efficient, point-of-care uroflometry for improved diagnosis, monitoring, and post-treatment evaluation of LUTS

    SBC: STREAM DX, INC            Topic: 300

    PROJECT SUMMARYABSTRACT Lower urinary tract symptomsLUTSis one of the most common medical problems among older menaffectingof men by the time they reachyears of age andby the time they reach the age ofLUTS is a progressive disease that has been shown to significantly increase the risk of depression and reduce quality of lifeDue to thisearly detection and active management of LUTS is criticalUroflo ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. ARF6 Inhibitors for Treatment of Acute Lung Injury

    SBC: NAVIGEN, INC.            Topic: NHLBI

    PROJECT SUMMARYAcute lung injuryALIand acute respiratory distress syndromeARDSresult from a common pathogenic processpulmonary injury or infection triggers an overwhelming inflammatory responsecytokine stormthat results in increased endothelial and epithelial permeability and efflux of inflammatory cellsproteinand water from the vascular system into the alveolar spaceThe further release of inflamm ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms

    SBC: THERATARGET, INC.            Topic: 106

    NARRATIVE This STTR Phase I proposal details the rationale and the research plan for the development of a novel liquid embolizing agent composed of the genetically engineered protein polymerSELPsilk elastinlike proteinKto embolize cerebral aneurysmsThe SELP embolic would reduce the risk of aneurysm rupture while minimizing the risk of recanalization after treatment and providing a platform for del ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Therapeutic D-peptide Inhibitor of HIV Entry

    SBC: NAVIGEN, INC.            Topic: R

    PROJECT SUMMARYWhile modern HIV combination therapy has transformed HIV into a manageable chronic infection for many patientsHIV AIDS remains a formidable global epidemicDespite the effectiveness of combining drugs from different classesside effects and drug resistance remain serious concerns for these life long therapiesThusthere is an enduring need for novel HIV inhibitors with new mechanisms of ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Visually driven disease variant analysis empowering real time clinical research

    SBC: FRAMESHIFT LABS INC            Topic: NHGRI

    Project Summary Identifying disease causing genetic variants is a complex process that requires experts from multiple fields including bioinformatics IT systems administration and disease pathology to work closely together The size of sequencing data files also adds the requirement for large computational resources As a result performing genomic analyses is an ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Cone Beam Tomosynthesis Fluoroscopy for Image Guided Interventions

    SBC: NVIEW MEDICAL            Topic: NCI

    PROJECT SUMMARY ABSTRACT nView medicalSurgical inaccuracies impact patient safety and increase healthcare costsSpinal fusions are a prime examplewithprocedures per year in the US it is the sixth most frequent procedure and reoperation rates areThereareanestimatedrevisionsurgeriesduetomisplacedscrewsthatcouldbeavoidedifintraoperativeD guidance was standardThe total cost of the revision surgeries du ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. D peptide inhibitors of SIRPα anti phagocytic signaling

    SBC: NAVIGEN, INC.            Topic: 100

    PROJECT SUMMARY The cell surface CD protein is a marker of self and signals through its receptor signal regulatory protein SIRP expressed by macrophages to transmit an anti phagocytic donandapos t eat me signal CD is expressed by virtually all cell types is overexpressed by cancer cells as a mechanism to avoid immune surveillance and phagocytosis and is a negative prognostic f ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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