Award Data

Increasing complexity of encryption used by criminals presents an ongoing challenge to law enforcement agencies. Effective code breaking attack methods have been developed for attacking many of the cryptosystems used by criminals, however, frequently attacking these files requires mammoth amounts of CPU power achieved only through the coordinated effort of hundreds or thousands of computers. Acces ...

The proposed research program aims at developing a variable-fidelity software tool set for aeroservothermoelastic-propulsive (ASTE-P) modeling that can be routinely applied to the design of aerospace vehicles. The tool set can be applied to conventional vehicle types as well as hypersonic vehicles. The major issues involved in ASTE-P modeling and simulation will be significantly and extensively in ...

The proposed research program aims to develop a physics-based identification, modeling and management infrastructure for aeroelastic limit-cycle oscillations. This infrastructure will be built upon high fidelity state-of-the-art theoretical/computational methods as validated and verified by available experimental data bases, and will include (1) rapid flutter boundary determination for a wide ran ...

This program is designed to development and implement portable friction stir welding for both repair and subassembly of Navy Al structures. This dual use requirement necessitates two different approaches. For example, subassembly implies relatively small structures and a moderate number of components. Further, subassemblies can be welded remote from their final assembly location and moved to, a ...

Advanced Simulation Displays (ASD) proposes to leverage the work already accomplished building seamless wide field of view displays utilizing commerical flat panel display technology. Three of these systems have been build and delivered utilizing fifty inch plasma panels combined to provide a seamless scene for UH-1H simulators. In addition, ASD is under contract to build three channel seamless ...

The technical objectives of this SBIR proposal include the design verification of a frangible composite ILS Glideslope Tower that will maintain existing tolerances and mission performance capabilities. Zephyr Engineering Services’ [ZES’] (formerly All-Tech Solutions, Inc. [ATSI] ), technical approach is based upon the probability demonstrated through Phase I analysis that a qualified, frangib ...

DESCRIPTION (provided by applicant): Treatment of alcohol use disorders (AUDs), commonly referred to as alcoholism, has been hampered by alcohol's promiscuous pharmacological effects and the complex etiology of addiction. People drink in excess for a variety of reasons, and an approach that targets more of these reasons will have greater commercial success than an approach that only targets a sole ...

DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) is an autoimmune disease that targets insulin secreting pancreatic beta cells for destruction and remains a major cause of morbidity and mortality in over 1% of the population worldwide. Although insulin therapy and islet transplantation are currently the most effective treatments, both of these approaches suffer from major limitations inc ...

DESCRIPTION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor associated antigen (TAA) to professional antigen-presenting cells (APCs) and activate them for the generation of an effective anti-tumor immune respon ...

DESCRIPTION (provided by applicant): Various cancer vaccines based on tumor associated antigens (TAAs) or tumor specific antigens (TSAs) have shown efficacy in preclinical models. However, their therapeutic efficacies have been rather limited in clinical trial settings. Although the reason for clinical inefficacy for these vaccines is not known, the lack of an adjuvant with potent immunostimulato ...