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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. COMPUTERIZED READING DIAGNOSIS AND REMEDIATION

    SBC: New Sage            Topic: N/A

    NEW SAGE HAS UNDERTAKEN THE DEVELOPMENT OF A COMPUTERIZED ENVIRONMENT FOR TESTING AND REMEDIATING A VARIETY OF READINGDISABILITIES. IT IS CALLED DELVE. THE TEST IS BASED ON A MULTIDIMENSIONAL MODEL OF READING SKILL COMPONENTS. DELVE PRESENTS ITEMS TO TEST ALL READING SKILL AREAS, PRESENTS A VARIETY OF DIAGNOSTIC DATA, SUGGESTS APPROPRIATE REMEDIATION, AND THEN PROVIDES GAMES DESIGNED TO BEEF UP WE ...

    SBIR Phase I 1990 Department of Education
  2. MULTIFUNCTIONAL ANTITHROMBOGENIC SURFACES

    SBC: Cardiopulmonics, Inc.            Topic: N/A

    THE LONG-TERM OBJECTIVES OF THIS PROJECT ARE THE METHODOLOGY DEVELOPMENT AND MANUFACTURING OF ANTITHROMBOGENIC SURFACES CONTAINING POLYETHYLENE OXIDE (PEO)-TETHERED BIOACTIVE COMPOUNDS THAT COUNTERACT OR INHIBIT THE MAJOR THROMBOGENIC EFFECTS KNOWN TO OCCUR WHEN A SURFACE IS EXPOSED TO BLOOD. THE SPECIFIC AIMS OF PHASE I ARE TO: (1) PRODUCE AND CHARACTERIZE IN DETAIL HEPARIN-ONLY AND UROKINASE-ONL ...

    SBIR Phase I 1990 Department of Health and Human Services
  3. NEW COUPLING GROUPS FOR AQUEOUS IMMOBILIZATION CHEMISTRY

    SBC: Cardiopulmonics, Inc.            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF NEW REAGENTS AND METHODOLOGIES FOR COUPLING POLYMERS AND ANTITHROMBOGENIC COMPOUNDS TO POLYMER SURFACES IN MULTISTEP SEQUENCES UNDER AQUEOUS CONDITIONS. THE SPECIFIC AIMS OF THE PHASE I RESEARCH ARE: (1) SYNTHESIS, CHARACTERIZATION, AND STABILITY STUDIES OF POLYETHYLENE OXIDE (PEO) SPACERS MODIFIED WITH NOVEL, WATER-STABLE END GROUPS; ( ...

    SBIR Phase I 1990 Department of Health and Human Services
  4. IMPROVED REPLACEMENT TECHNOLOGY FOR RFLP ANALYSIS

    SBC: Ceres/npi            Topic: N/A

    RFLP ANALYSIS HAS BEEN SHOWN TO HAVE TREMENDOUS IMPLICATIONSFOR BOTH THE DIAGNOSIS OF GENETIC TENDENCIES FOR HUMAN DISEASE AND FOR APPLICATIONS TO PLANT AND ANIMAL IMPROVEMENT; UNFORTUNATELY, THE DEMANDS FOR ITS USE HAVE OUTSTRIPPED THE CAPACITY OF WHAT IS PRIMARILY A RESEARCH TECHNOLOGY. A REPLACEMENT TECHNOLOGY IS DESIRED THAT IS FASTER, CHEAPER, AND WITH A HIGHER THROUGHPUT BUT, AT THE SAME TIM ...

    SBIR Phase II 1990 Department of Health and Human Services
  5. RECORD-LINKING SYSTEM FOR GENETICS AND EPIDEMIOLOGY

    SBC: Dms Systems Inc            Topic: N/A

    MANY GENETIC AND EPIDEMIOLOGIC STUDIES RELY ON LINKING RECORDS IN SEPARATE FILES THAT REFER TO THE SAME INDIVIDUAL. THE PURPOSE OF THIS PROJECT IS TO DESIGN AND BEGIN IMPLEMENTATION OF A PROTOTYPE OF A SYSTEM THAT FACILITATES LINKING RECORDS WHERE THE IDENTIFYING INFORMATION BETWEEN RECORDS IS NOT IDENTICAL. ALTHOUGH A GENERAL THEORY OF RECORD LINKING HAS EVOLVED OVER THE LAST SEVERAL DECADES, NO ...

    SBIR Phase I 1990 Department of Health and Human Services
  6. FAMILIES IN FOCUS PREVENTION PROGRAM FOR HISPANIC FAMILIES

    SBC: Families In Focus Inc            Topic: N/A

    THIS PROJECT WILL DEVELOP EDUCATIONAL MATERIALS FOR USE WITHAN ETHNIC MINORITY POPULATION. THE HISPANIC POPULATION IS AMERICA'S FASTEST GROWING ETHNIC GROUP. CENSUS DATA INDICATE THIS POPULATION IS LESS EDUCATED AND MORE ECONOMICALLY DISADVANTAGED THAN THEIR ANGLO-AMERICAN COUNTERPARTS. RESEARCH STUDIES HAVE CONSISTENTLY DEMONSTRATED OVERREPRESENTATION IN ALCOHOL/DRUG NEED SURVEYSAND IN TREATMENT ...

    SBIR Phase I 1990 Department of Health and Human Services
  7. SYNTHETIC PEPTIDE AS CAPTURE AG FOR PARVOVIRUS IGG AND IGM

    SBC: Gull Laboratories Inc            Topic: N/A

    THE HUMAN PARVOVIRUS B19 (HPV B19), THE AGENT OF ERYTHEMA CONTAGIOSUM, APLASTIC CRISIS, AND HYDROPS FETALIS AMONG OTHER DISEASE STATES CANNOT BE CULTIVATED USING CONVENTIONALMETHODS AND IS DIFFICULT TO COLLECT FROM PATIENTS. THIS PROJECT WILL DEVELOP AN ASSAY TO DETECT SERUM ANTIBODIES AGAINST HPV B19, USING SYNTHETIC PEPTIDES AS CAPTURE ANTIGENS. FIRST, MAJOR EPITOPES WERE LOCALIZED ON THE VIRAL ...

    SBIR Phase I 1990 Department of Health and Human Services
  8. SYNTHETIC PEPTIDES AS CAPTURE ANTIGENS FOR LYME ELISA

    SBC: Gull Laboratories Inc            Topic: N/A

    CURRENTLY, THE SEROLOGICAL DIAGNOSIS OF LYME DISEASE IS COMPLICATED BY CROSS-REACTIVITY WITH OTHER MICROBES, INCLUDING DISEASE AGENTS. A 41-KDA FLAGELLAR PROTEIN (FLAGELLIN) OF BORRELIA BURGDORFERI HAS BEEN SHOWN BOTH TO BE AN IMMUNODOMINANT ANTIGEN (IGM AGAINST THIS ANTIGEN THAT ARISES EARLY DURING INFECTION) AND TO POSSESS EPITOPES THAT ARE UNIQUE TO THE GENUS BORRELIA. THE NUCLEIC ACID SEQUENCE ...

    SBIR Phase I 1990 Department of Health and Human Services
  9. LIGHT EQUALIZATION RADIOGRAPHIC SCREEN/FILM CASSETTE

    SBC: Innovative Imaging Sciences            Topic: N/A

    THE DEVELOPMENT OF A NOVEL ELECTRONIC SCREEN/FILM CASSETTE FOR USE IN MEDICAL X-RAY IMAGING (RADIOGRAPHY) IS PROPOSED. DURING PHASE I, A STANDARD CASSETTE WILL BE MODIFIED BY ADDING A TWO DIMENSIONAL ARRAY OF PHOTODETECTORS INTERDIGITATED WITH A SECOND ARRAY OF LIGHT EMITTING DIODES (LED'S), PLACED BEHIND THE BACK INTENSIFYING SCREEN. THE PHOTODETECTORS, ACTIVATED DURING A RADIOGRAPHIC EXPOSURE, W ...

    SBIR Phase II 1990 Department of Health and Human Services
  10. VIDEO IMAGE PROCESSOR FOR FLUOROSCOPIC DOSE REDUCTION

    SBC: Innovative Imaging Sciences            Topic: N/A

    OVER THE PAST 20 YEARS, VARIOUS METHODS FOR REDUCING THE AMOUNT OF RADIATION EXPOSURE ASSOCIATED WITH FLUOROSCOPIC EXAMINATIONS HAVE BEEN SUGGESTED. SOME HAVE BEEN IMPLEMENTED, BUT NONE HAVE FOUND THEIR WAY INTO THE MAINSTREAM OF ROUTINE CLINICAL PRACTICE. PREVIOUS METHODS HAVE FAILED FOR A NUMBER OF REASONS: INADEQUATE TEMPORAL RESOLUTION, CUMBERSOME INSTRUMENTATION, UNACCEPTABLE MOTION ARTIFACTS ...

    SBIR Phase I 1990 Department of Health and Human Services

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