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Thermal dilution is by far the most common method of measuring cardiac output. Over onemillion thermodilution pulmonary artery catheters are used each year in the U.S. We have appliedartificial neural networks to improve the accuracy of the thermal dilution cardiac output measurementand allow using small injectate volumes (2 ml). We will build an automated system using a modifiedsyringe pump and a ...

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We will establish the feasibility for applying a new and noninvasive method to the developmentof a practical instrument for sensitive and quantitative detection of microembolic involvement in humanlungs. Because present methods for detection of pulmonary emboli utilize imaging techniques, the sizeof emboli detectable by these methods are limited by the inherent spacial resolution of x-ray and gamm ...

INITIAL DESIGN AND TESTING OF THE MICROMATH SCIENTIFIC COMPUTING ENVIRONMENT (MMSCE) WILL BE CARRIED OUT. THE MMSCE EMBODIES AN OBJECT ORIENTED APPROACH TO SCIENTIFIC COMPUTING. "COMPUTATIONAL NODES" ARE DEFINED HERE AS ENTITIES BETWEEN WHICH DATA AND OTHER MESSAGES FLOW. IN THE MMSCE, THE SCENTIST-USER MANIPULATES COMPUTATIONAL NODES, AUTOMCATICALLY LINKING POTENTIALLY DIVERSE TYPES OF SCIENTIFIC ...

Our purpose is to develop orthotic devices that will improve hand function for people withparalyzed upper limbs. Existing devices that allow for some hand function for people with paralyzedupper limbs are based on the World Health Organization 1954 tenodesis orthotic splint. Developmentsover the past decade have provided the possibility for devising orthoses that can be controlled by signalsfrom s ...

The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor has been implicated in avariety of neurological pathologies including ischemic brain damage (stroke), head trauma, spinal cordinjury, epilepsy, neurodegenerative disorders such as Alzheimer's Disease, and hyperalgesic states. Thedevelopment of NMDA antagonists as therapeutants, however, has been hampered by the occurrenceof deleterious ...

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Thermal dilution, the most common method used for determining cardiac output, is highlytechnique dependant and yields results that may be off as much as +/- 2O%. To reduce error, theprocedure is often repeated a number of times and the average of all of the readings taken. Each readingrequires a bolus injection of solution, increasing the risk of sepsis and fluid overload. Modifications tothis tec ...